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Discovery of fevipiprant (NVP-QAW039), a potent and selective DP2 receptor antagonist for treatment of asthma

Sandham, David A.; Barker, Lucy; Brown, Lyndon; Brown, Zarin; Budd, David; Charlton, Steven J.; Chatterjee, Devnanden; Cox, Brian; Dubois, Gerald; Duggan, Nicholas; Hall, Edward; Hatto, Julia; Maas, Janet; Manini, Jodie; Profit, Rachael; Riddy, Darren; Ritchie, Catherine; Sohal, Bindi; Shaw, Duncan; Stringer, Rowan; Sykes, David A.; Thomas, Matthew; Turner, Katherine L.; Watson, Simon J.; West, Ryan; Willard, Elisabeth; Williams, Gareth; Willis, Jennifer


David A. Sandham

Lucy Barker

Lyndon Brown

Zarin Brown

David Budd

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Professor of Molecular Pharmacology and Drug Discovery

Devnanden Chatterjee

Brian Cox

Gerald Dubois

Nicholas Duggan

Edward Hall

Julia Hatto

Janet Maas

Jodie Manini

Rachael Profit

Darren Riddy

Catherine Ritchie

Bindi Sohal

Duncan Shaw

Rowan Stringer

David A. Sykes

Matthew Thomas

Katherine L. Turner

Simon J. Watson

Ryan West

Elisabeth Willard

Gareth Williams

Jennifer Willis


Further optimization of an initial DP2 receptor antagonist clinical candidate NVPQAV680 led to the discovery of a follow-up molecule 2-(2-methyl-1-(4-(methylsulfonyl)-2- (trifluoromethyl)benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid (compound 11, NVP-QAW039, fevipiprant), which exhibits improved potency on human eosinophils and Th2 cells, together with a longer receptor residence time, and is currently in clinical trials for severe asthma.


Sandham, D. A., Barker, L., Brown, L., Brown, Z., Budd, D., Charlton, S. J., …Willis, J. (2017). Discovery of fevipiprant (NVP-QAW039), a potent and selective DP2 receptor antagonist for treatment of asthma. ACS Medicinal Chemistry Letters, 8(5), 582-586.

Journal Article Type Article
Acceptance Date Apr 25, 2017
Online Publication Date Apr 27, 2017
Publication Date May 11, 2017
Deposit Date Jul 12, 2017
Journal ACS Medicinal Chemistry Letters
Print ISSN 1948-5875
Electronic ISSN 1948-5875
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 8
Issue 5
Pages 582-586
Keywords DP2 receptor antagonist, severe asthma, clinical candidate
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