Yim-Yee Matthews
Pseudotumor cerebri syndrome in childhood: incidence, clinical profile and risk factors in a national prospective population-based cohort study
Matthews, Yim-Yee; Dean, Fiona; Lim, Ming J.; Mclachlan, Karen; Rigby, Alan S.; Solanki, Guirish A.; White, Catherine P.; Whitehouse, William P.; Kennedy, Colin R.
Authors
Fiona Dean
Ming J. Lim
Karen Mclachlan
Alan S. Rigby
Guirish A. Solanki
Catherine P. White
William P. Whitehouse
Colin R. Kennedy
Abstract
AIM:
To investigate the epidemiology, clinical profile and risk factors of pseudotumor cerebri syndrome (PTCS) in children aged 1-16 years.
METHODS:
A national prospective population-based cohort study over 25 months. Newly diagnosed PTCS cases notified via British Paediatric Surveillance Unit were ascertained using classical diagnostic criteria and categorised according to 2013 revised diagnostic criteria. We derived national age, sex and weight-specific annual incidence rates and assessed effects of sex and weight categories.
RESULTS:
We identified 185 PTCS cases of which 166 also fulfilled revised diagnostic criteria. The national annual incidence (95% CI) of PTCS in children aged 1-16 years was 0.71 (0.57 to 0.87) per 100 000 population increasing with age and weight to 4.18 and 10.7 per 100 000 in obese boys and girls aged 12-15 years, respectively. Incidence rates under 7 years were similar in both sexes. From 7 years onwards, the incidence in girls was double that in boys, but only in overweight (including obese) children. In children aged 12-15 years, an estimated 82% of the incidence of PTCS was attributable to obesity. Two subgroups of PTCS were apparent: 168 (91%) cases aged from 7 years frequently presented on medication and with headache and were predominantly female and obese. The remaining 17 (9%) cases under 7 years often lacked these risk factors and commonly presented with paralytic squint.
CONCLUSIONS:
This uniquely large population-based study of childhood PTCS will inform the design of future intervention studies. It suggests that weight reduction is central to the prevention of PTCS.
Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.
Citation
Matthews, Y.-Y., Dean, F., Lim, M. J., Mclachlan, K., Rigby, A. S., Solanki, G. A., …Kennedy, C. R. (in press). Pseudotumor cerebri syndrome in childhood: incidence, clinical profile and risk factors in a national prospective population-based cohort study. Archives of Disease in Childhood, 102(8), https://doi.org/10.1136/archdischild-2016-312238
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 3, 2017 |
Online Publication Date | Mar 29, 2017 |
Deposit Date | Apr 5, 2018 |
Publicly Available Date | Apr 5, 2018 |
Journal | Archives of Disease in Childhood |
Print ISSN | 0003-9888 |
Electronic ISSN | 1468-2044 |
Publisher | BMJ Publishing Group |
Peer Reviewed | Peer Reviewed |
Volume | 102 |
Issue | 8 |
DOI | https://doi.org/10.1136/archdischild-2016-312238 |
Keywords | BPSU; Epidemiology; Obesity; Idiopathic intracranial hypertension; Pseudotumor cerebri |
Public URL | https://nottingham-repository.worktribe.com/output/852624 |
Publisher URL | http://adc.bmj.com/content/102/8/715 |
Contract Date | Apr 5, 2018 |
Files
Matthews_et_al_ADC_Jan_2017_revised_clean IIH (1).pdf
(331 Kb)
PDF
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search