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Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women

Alshammari, G.; Khan, Raheela; Brameld, John M.; Amer, Saad A.; Lomax, Michael A.

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Authors

G. Alshammari

RAHEELA KHAN RAHEELA.KHAN@NOTTINGHAM.AC.UK
Professor of Cellular Physiology

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JOHN BRAMELD JOHN.BRAMELD@NOTTINGHAM.AC.UK
Professor of Nutritional Biochemistry

Saad A. Amer

Michael A. Lomax



Abstract

OBJECTIVE: The pathogenesis of polycystic ovary syndrome (PCOS), a common endocrine disease and metabolic disturbance, is still unknown. The aim of the study was to investigate whether patients with PCOS display increased expression of inflammatory markers in adipose tissue.
PATIENTS AND METHODS: Two groups of women were investigated, those diagnosed with PCOS (n = 8) and age and BMI-matched normal women (n = 12). Their age was between 20-45 years and all subjects were apparently healthy and did not take any medications. Adipose tissue levels of mRNA of inflammatory markers were determined by use of real-time PCR.
RESULTS: There were no differences between obese patients and obese PCOS in levels of adipocytokines.
CONCLUSIONS: There were no effects of PCOS on the expression of any of the adipocytokines genes measured in subcutaneous adipose tissue.

Citation

Alshammari, G., Khan, R., Brameld, J. M., Amer, S. A., & Lomax, M. A. (2017). Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women. European Review for Medical and Pharmacological Sciences, 21(5),

Journal Article Type Article
Acceptance Date Mar 20, 2017
Publication Date Mar 23, 2017
Deposit Date Mar 24, 2017
Publicly Available Date Mar 24, 2017
Journal European Review for Medical and Pharmacological Sciences
Electronic ISSN 2284-0729
Peer Reviewed Peer Reviewed
Volume 21
Issue 5
Keywords Polycystic ovary syndrome, Insulin resistance, Inflammation
Public URL https://nottingham-repository.worktribe.com/output/851622
Publisher URL http://www.europeanreview.org/article/12334
Contract Date Mar 24, 2017

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