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Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation?

Steenblock, Charlotte; de Celis, Maria F. Rubin; Androutsellis-Theotokis, Andreas; Sue, Mariko; Delgadillo Silva, Luis F.; Eisenhofer, Graeme; Andoniadou, Cynthia L.; Bornstein, Stefan R.


Charlotte Steenblock

Maria F. Rubin de Celis

Andreas Androutsellis-Theotokis

Mariko Sue

Luis F. Delgadillo Silva

Graeme Eisenhofer

Cynthia L. Andoniadou

Stefan R. Bornstein


The adrenal gland is a highly plastic organ with the capacity to adapt the body homeostasis to different physiological needs. The existence of stem-like cells in the adrenal cortex has been revealed in many studies. Recently, we identified and characterized in mice a pool of glia-like multipotent Nestin-expressing progenitor cells, which contributes to the plasticity of the adrenal medulla. In addition, we found that these Nestin progenitors are actively involved in the stress response by giving rise to chromaffin cells. Interestingly, we also observed a Nestin-GFP-positive cell population located under the adrenal capsule and scattered through the cortex. In this article, we discuss the possibility of a common progenitor giving rise to subpopulations of cells both in the adrenal cortex and medulla, the isolation and characterization of this progenitor as well as its clinical potential in transplantation therapies and in pathophysiology.

Journal Article Type Article
Acceptance Date Sep 12, 2016
Online Publication Date Sep 13, 2016
Publication Date Feb 5, 2017
Deposit Date May 9, 2017
Journal Molecular and Cellular Endocrinology
Print ISSN 0303-7207
Electronic ISSN 1872-8057
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 441
Keywords adrenal medulla, adrenal cortex, stem cells, progenitors, stress, nestin
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