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The Nottingham Fatigue After Stroke (NotFAST) study: factors associated with severity of fatigue in stroke patients without depression

Drummond, Avril E.R.; Hawkins, Loiuse; Sprigg, Nikola; Ward, Nick S.; Mistri, Amit; Tyrrell, Pippa; Mead, Gillian E.; Worthington, Esme; Lincoln, Nadina

Authors

AVRIL DRUMMOND avril.drummond@nottingham.ac.uk
Professor of Healthcare Research

Loiuse Hawkins

NIKOLA SPRIGG nikola.sprigg@nottingham.ac.uk
Professor of Stroke Medicine

Nick S. Ward

Amit Mistri

Pippa Tyrrell

Gillian E. Mead

Esme Worthington esme.worthington@nottingham.ac.uk

Nadina Lincoln Nadina.Lincoln@nottingham.ac.uk



Abstract

Objective: To identify factors associated with post-stroke fatigue in a sample of stroke survivors without depression.
Design: Cross-sectional cohort study.
Setting: Recruitment was from four stroke units in the UK.
Subjects: Participants were assessed within four weeks of first stroke; those with high levels of depressive symptoms (score ≥7 Brief Assessment Schedule Depression Cards) were excluded.
Main measures: Participants were assessed four to six weeks after stroke on the Fatigue Severity Subscale of the Fatigue Assessment Inventory, the Rivermead Mobility Index, Nottingham Extended Activities of Daily Living scale, Beck Anxiety Index, Sleep Hygiene Index, 6m walk test, and measures of cognitive ability.
Results: Of the 371 participants recruited, 103 were excluded and 268 were assessed. Of the latter, the mean age was 67.7 years (SD 13.5) and 168 (63%) were men. The National Institutes of Health Stroke Scale mean score was 4.96 (SD 4.12). Post-stroke fatigue was reported by 115 (43%) of participants, with 71 (62%) reporting this to be a new symptom since their stroke. Multivariate analysis using the Fatigue Severity Scale as the outcome variable found pre-stroke fatigue, having a spouse/partner, lower Rivermead Mobility Index score, and higher scores on both the Brief Assessment Schedule Depression Cards and Beck Anxiety Index were independently associated with post-stroke fatigue, accounting for approximately 47% of the variance in Fatigue Severity Scale scores.
Conclusions: Pre-stroke fatigue, lower mood, and poorer mobility were associated with post-stroke fatigue.

Journal Article Type Article
Journal Clinical Rehabilitation
Print ISSN 0269-2155
Electronic ISSN 1477-0873
Publisher SAGE Publications
Peer Reviewed Peer Reviewed
APA6 Citation Drummond, A. E., Hawkins, L., Sprigg, N., Ward, N. S., Mistri, A., Tyrrell, P., …Lincoln, N. (in press). The Nottingham Fatigue After Stroke (NotFAST) study: factors associated with severity of fatigue in stroke patients without depression. Clinical Rehabilitation, https://doi.org/10.1177/0269215517695857
DOI https://doi.org/10.1177/0269215517695857
Keywords Stroke, fatigue, correlation, depression, mood
Publisher URL http://journals.sagepub.com/action/doSearch?SeriesKey=crea&AllField=NotFast+study
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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