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sTREM-1 is elevated in cystic fibrosis and correlates with proteases

Forrester, D.L.; Barr, Helen L.; Fogarty, A.; Knox, A.

sTREM-1 is elevated in cystic fibrosis and correlates with proteases Thumbnail


Authors

D.L. Forrester

Helen L. Barr

ANDREW FOGARTY ANDREW.FOGARTY@NOTTINGHAM.AC.UK
Clinical Associate Professor & Reader in Clinical Epidemiology

A. Knox



Abstract

Background: sTREM-1 (soluble triggering receptor expressed on myeloid cells-1) is a novel inflammatory marker that may be of clinical use in cystic fibrosis (CF). Dysregulation of the TREM pathway has been demonstrated in other inflammatory diseases and modulation in animal models has therapeutic benefit. We hypothesised that sTREM-1 could act as a biomarker of disease in cystic fibrosis.

Methods: Plasma from 17 patients with CF (stable and pre and post pulmonary exacerbation) and eight healthy volunteers was analyzed for sTREM-1 and proteases (matrix metalloproteinase-8 (MMP-8), MMP-9, and human neutrophil elastase HNE).

Results: sTREM-1 Levels were elevated in stable CF subjects compared to controls (148 pg/ml (130–160) [median(IQR)] vs. 87 (55–118) (P < 0.01)) but were not further increased during pulmonary exacerbation nor decreased after antibiotic treatment in CF. Protease levels were increased in CF plasma compared to controls: MMP–8 = 3.1 ng/ml (1.5–7.6) vs. 0.3 (0.18–0.53) (P < 0.01) (Wilcoxon); MMP–9 = 170 ng/ml (124–282) vs. 49 (39–90) (P <  0.01); HNE = 30.2 ng/ml (22.7–30.9) vs. 17.5 (11.2–22.2) (P < 0.05). sTREM-1 correlated positively with protease levels lnMMP-8 r2 = 0.55 (P = 0.08), lnMMP-9 r2 =  0.61(P < 0.05), lnHNE r2 = 0.35 (P < 0.05).

Conclusions: sTREM-1 is constitutively elevated in CF and positively correlates with protease levels. Modulation of this pathway may be of therapeutic benefit to patients with CF.

Citation

Forrester, D., Barr, H. L., Fogarty, A., & Knox, A. (2017). sTREM-1 is elevated in cystic fibrosis and correlates with proteases. Pediatric Pulmonology, 52(4), 467-471. https://doi.org/10.1002/ppul.23650

Journal Article Type Article
Acceptance Date Nov 17, 2016
Online Publication Date Jan 9, 2017
Publication Date 2017-04
Deposit Date Jul 12, 2017
Publicly Available Date Jul 12, 2017
Journal Pediatric Pulmonology
Print ISSN 8755-6863
Electronic ISSN 1099-0496
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 52
Issue 4
Pages 467-471
DOI https://doi.org/10.1002/ppul.23650
Keywords inflammation, MMPs, biomarkers
Public URL https://nottingham-repository.worktribe.com/output/841156
Publisher URL http://onlinelibrary.wiley.com/doi/10.1002/ppul.23650/abstract
Additional Information This is the peer reviewed version of the following article: Forrester, D.L., Barr, H.L., Fogarty, A. and Knox, A. (2017), sTREM-1 is elevated in cystic fibrosis and correlates with proteases. Pediatric Pulmonology, 52: 467–471., which has been published in final form at http://dx.doi.org/10.1002/ppul.23650. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Contract Date Jul 12, 2017

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