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Extracellular matrix hydrogels from decellularized tissues: structure and function

Saldin, Lindsey T.; Cramer, Madeline C; Velankar, Sachin S; White, Lisa J.; Badylak, Stephen F.

Authors

Lindsey T. Saldin

Madeline C Cramer

Sachin S Velankar

Stephen F. Badylak



Abstract

Extracellular matrix (ECM) bioscaffolds prepared from decellularized tissues have been used to facilitate constructive and functional tissue remodeling in a variety of clinical applications. The discovery that these ECM materials could be solubilized and subsequently manipulated to form hydrogels expanded their potential in vitro and in vivo utility; i.e. as culture substrates comparable to collagen or Matrigel, and as injectable materials that fill irregularly-shaped defects. The mechanisms by which ECM hydrogels direct cell behavior and influence remodeling outcomes are only partially understood, but likely include structural and biological signals retained from the native source tissue. The present review describes the utility, formation, and physical and biological characterization of ECM hydrogels. Two examples of clinical application are presented to demonstrate in vivo utility of ECM hydrogels in different organ systems. Finally, new research directions and clinical translation of ECM hydrogels are discussed

Citation

Saldin, L. T., Cramer, M. C., Velankar, S. S., White, L. J., & Badylak, S. F. (2017). Extracellular matrix hydrogels from decellularized tissues: structure and function. Acta Biomaterialia, 49, https://doi.org/10.1016/j.actbio.2016.11.068

Journal Article Type Article
Acceptance Date Nov 30, 2016
Online Publication Date Dec 1, 2016
Publication Date Feb 1, 2017
Deposit Date Sep 15, 2017
Publicly Available Date Mar 29, 2024
Journal Acta Biomaterialia
Print ISSN 1742-7061
Electronic ISSN 1878-7568
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 49
DOI https://doi.org/10.1016/j.actbio.2016.11.068
Keywords Extracellular matrix; Hydrogel; Decellularization; Naturally derived; Injectable; Regenerative medicine; Biomaterial; Tissue engineering
Public URL https://nottingham-repository.worktribe.com/output/837520
Publisher URL http://www.sciencedirect.com/science/article/pii/S174270611630664X?via%3Dihub

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