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Exploring the reactivity of 2-trichloromethylbenzoxazoles for access to substituted benzoxazoles

Lester, Roy P.; Bham, Travis; Bousfield, Thomas W.; Lewis, William; Camp, Jason E.

Authors

Roy P. Lester r.lester@scientist.com

Travis Bham

Thomas W. Bousfield

William Lewis

Jason E. Camp



Abstract

The reactivity of 2-trichloromethylbenzoxazoles towards various nucleophiles, under metal free or iron-catalyzed conditions, for the synthesis of substituted benzoxazoles is described. These methods allow for selective substitution at either the 2- or 2’- position of the benzoxazoles using the same starting materials / reagents. This approach allows for the controlled synthesis of a variety of key derivatives from a single 2-trichloromethylbenzoxazole starting material.

Citation

Lester, R. P., Bham, T., Bousfield, T. W., Lewis, W., & Camp, J. E. (in press). Exploring the reactivity of 2-trichloromethylbenzoxazoles for access to substituted benzoxazoles. Journal of Organic Chemistry, 84(24), https://doi.org/10.1021/acs.joc.6b02315

Journal Article Type Article
Acceptance Date Dec 6, 2016
Online Publication Date Dec 6, 2016
Deposit Date Jan 17, 2017
Publicly Available Date Jan 17, 2017
Journal Journal of Organic Chemistry
Print ISSN 0022-3263
Electronic ISSN 1520-6904
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 84
Issue 24
DOI https://doi.org/10.1021/acs.joc.6b02315
Public URL http://eprints.nottingham.ac.uk/id/eprint/39891
Publisher URL http://pubs.acs.org/doi/abs/10.1021/acs.joc.6b02315
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf

Files


2016 JECamp JOCNote .pdf (379 Kb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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