Skip to main content

Research Repository

Advanced Search

Pharmacology of modulators of alternative splicing

Bates, David O.; Morris, Jonathan C.; Oltean, Sebastian; Donaldson, Lucy F.

Pharmacology of modulators of alternative splicing Thumbnail


Authors

Jonathan C. Morris

Sebastian Oltean

Lucy F. Donaldson



Abstract

More than 95% of genes in the human genome are alternatively spliced to form multiple transcripts, often encoding proteins with differing or opposing function. The control of alternative splicing is now being elucidated, and with this comes the opportunity to develop modulators of alternative splicing that can control cellular function. A number of approaches have been taken to develop compounds that can experimentally, and sometimes clinically, affect splicing control resulting in potential novel therapeutics. Here we develop the concepts that targeting alternative splicing can result in relatively specific pathway inhibitors/activators that result in dampening down of physiological or pathological processes, from changes in muscle physiology, to altering angiogenesis or pain. The targets and pharmacology of some of the current inhibitors/activators of alternative splicing are demonstrated and future directions discussed.

Citation

Bates, D. O., Morris, J. C., Oltean, S., & Donaldson, L. F. (2017). Pharmacology of modulators of alternative splicing. Pharmacological Reviews, 69(1), https://doi.org/10.1124/pr.115.011239

Journal Article Type Article
Acceptance Date Oct 25, 2016
Publication Date Jan 1, 2017
Deposit Date Dec 19, 2016
Publicly Available Date Jan 1, 2017
Journal Pharmacological Reviews
Print ISSN 0031-6997
Electronic ISSN 1521-0081
Publisher American Society for Pharmacology and Experimental Therapeutics
Peer Reviewed Peer Reviewed
Volume 69
Issue 1
DOI https://doi.org/10.1124/pr.115.011239
Public URL https://nottingham-repository.worktribe.com/output/830468
Publisher URL http://pharmrev.aspetjournals.org/content/69/1/63
Contract Date Dec 19, 2016

Files





You might also like



Downloadable Citations