Selective sweep on human amylase genes postdates the split with Neanderthals

Inchley, Charlotte E.; Larbey, Cynthia D.A.; Shwan, Nzar A.A.; Pagani, Luca; Saag, Lauri; Ant�o, Tiago; Jacobs, Guy; Hudjashov, Georgi; Metspalu, Ene; Mitt, Mario; Eichstaedt, Christina A.; Malyarchuk, Boris; Derenko, Miroslava; Wee, Joseph; Abdullah, Syafiq; Ricaut, Fran�ois-Xavier; Mormina, Maru; M�gi, Reedik; Villems, Richard; Metspalu, Mait; Jones, Martin K.; Armour, John A.L.; Kivisild, Toomas

Abstract

Humans have more copies of amylase genes than other primates. It is still poorly understood, however, when the copy number expansion occurred and whether its spread was enhanced by selection. Here we assess amylase copy numbers in a global sample of 480 high coverage genomes and find that regions flanking the amylase locus show notable depression of genetic diversity both in African and non-African populations. Analysis of genetic variation in these regions supports the model of an early selective sweep in the human lineage after the split of humans from Neanderthals which led to the fixation of multiple copies of AMY1 in place of a single copy. We find evidence of multiple secondary losses of copy number with the highest frequency (52%) of a deletion of AMY2A and associated low copy number of AMY1 in Northeast Siberian populations whose diet has been low in starch content.

Citation

Inchley, C. E., Larbey, C. D., Shwan, N. A., Pagani, L., Saag, L., Antão, T., …Kivisild, T. (in press). Selective sweep on human amylase genes postdates the split with Neanderthals. Scientific Reports, 6, https://doi.org/10.1038/srep37198

• Journal Article Type: Article
• Acceptance Date: Oct 25, 2016
• Online Publication Date: Nov 17, 2016
• Deposit Date: Jan 13, 2017
• Publicly Available Date: Jan 13, 2017
• Journal: Scientific Reports
• Electronic ISSN: 2045-2322
• Publisher: Nature Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 6
• DOI: https://doi.org/10.1038/srep37198
• Public URL: https://nottingham-repository.worktribe.com/output/828086
• Publisher URL: http://www.nature.com/articles/srep37198
• Contract Date: Jan 13, 2017