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A laboratory-scale annular continuous flow reactor for UV photochemistry using excimer lamps for discrete wavelength excitation and its use in a wavelength study of a photodecarboxlyative cyclisation

DeLaney, Erica N.; Lee, Darren S.; Elliott, Luke D.; Jin, Jing; Booker-Milburn, Kevin; Poliakoff, Martyn; George, Michael W.

A laboratory-scale annular continuous flow reactor for UV photochemistry using excimer lamps for discrete wavelength excitation and its use in a wavelength study of a photodecarboxlyative cyclisation Thumbnail


Authors

Erica N. DeLaney

Darren S. Lee

Luke D. Elliott

Jing Jin

Kevin Booker-Milburn



Abstract

This paper describes a new annular reactor for continuous UV photochemistry, which uses easily interchangeable excimer lamps of different wavelengths. The reactor has narrow clearance to form thin films of material for efficient irradiation of molecules. Its use is demonstrated by investigating the effect of discrete wavelength lamps (222, 282 and 308 nm) on the reaction of potassium N-phthalimidobutanoate 1. The ability of the reactor to be integrated into multistep processes is illustrated by combining it with an Amberlyst scavenger and a solid acid catalyst, NbOPO4, to access a second product 3 that is obtained in a single telescoped process. The tricyclic scaffold in 3 is a motif found in several biologically active compounds and has possibilities as a synthon for new pharmaceutical products.

Journal Article Type Article
Acceptance Date Nov 14, 2016
Online Publication Date Nov 23, 2016
Publication Date 2017
Deposit Date Mar 9, 2017
Publicly Available Date Mar 9, 2017
Journal Green Chemistry
Print ISSN 1463-9262
Electronic ISSN 1463-9270
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 19
Issue 6
Pages 1431-1438
DOI https://doi.org/10.1039/C6GC02888H
Public URL https://nottingham-repository.worktribe.com/output/827229
Publisher URL http://pubs.rsc.org/en/content/articlelanding/2017/gc/c6gc02888h#!divAbstract

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