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Malignant inflammation in cutaneous T-cell lymphoma: a hostile takeover

Krejsgaard, Thorbjørn; Lindahl, Lise M; Mongan, Nigel P.; Wasik, Mariusz A.; Litvinov, Ivan V.; Iversen, Lars; Langhoff, Erik; Woetmann, Anders; Odum, Niels


Thorbjørn Krejsgaard

Lise M Lindahl

Nigel P. Mongan

Mariusz A. Wasik

Ivan V. Litvinov

Lars Iversen

Erik Langhoff

Anders Woetmann

Niels Odum


Cutaneous T-cell lymphomas (CTCL) are characterized by the presence of chronically inflamed skin lesions containing malignant T cells. Early disease presents as limited skin patches or plaques and exhibits an indolent behavior. For many patients, the disease never progresses beyond this stage, but in approximately one third of patients, the disease becomes progressive, and the skin lesions start to expand and evolve. Eventually, overt tumors develop and the malignant T cells may disseminate to the blood, lymph nodes, bone marrow, and visceral organs, often with a fatal outcome. The transition from early indolent to progressive and advanced disease is accompanied by a significant shift in the nature of the tumor-associated inflammation. This shift does not appear to be an epiphenomenon but rather a critical step in disease progression. Emerging evidence supports that the malignant T cells take control of the inflammatory environment, suppressing cellular immunity and anti-tumor responses while promoting a chronic inflammatory milieu that fuels their own expansion. Here, we review the inflammatory changes associated with disease progression in CTCL and point to their wider relevance in other cancer contexts. We further define the term "malignant inflammation" as a pro-tumorigenic inflammatory environment orchestrated by the tumor cells and discuss some of the mechanisms driving the development of malignant inflammation in CTCL.


Krejsgaard, T., Lindahl, L. M., Mongan, N. P., Wasik, M. A., Litvinov, I. V., Iversen, L., …Odum, N. (in press). Malignant inflammation in cutaneous T-cell lymphoma: a hostile takeover. Seminars in Immunopathology,

Journal Article Type Article
Acceptance Date Sep 14, 2016
Online Publication Date Oct 7, 2016
Deposit Date Oct 10, 2016
Publicly Available Date Oct 10, 2016
Journal Seminars in Immunopathology
Print ISSN 1863-2297
Electronic ISSN 1863-2300
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Keywords Cutaneous T-cell lymphoma, Malignant T cells, Inflammation, Pathogenesis, Cancer, Infection
Public URL
Publisher URL
Copyright Statement Copyright information regarding this work can be found at the following address:


art%3A10.1007%2Fs00281-016-0594-9.pdf (4.7 Mb)

Copyright Statement
Copyright information regarding this work can be found at the following address:

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