Prognostic factors for long-term outcomes in relapsing–remitting multiple sclerosis

Traboulsee, Anthony L.; Cornelisse, Peter; Sandberg-Wollheim, Magnhild; Uitdehaag, Bernard M.J.; Kappos, Ludwig; Jongen, Peter J.; Constantinescu, Cris S.; Verdun di Cantogno, Elisabetta; Li, David K.B.

Abstract

Objective: The objective of this article is to investigate potential clinical and MRI predictors of long-term outcomes in multiple sclerosis (MS).

Methods: This was a post hoc analysis using data from all 382 patients in the PRISMS long-term follow-up (LTFU) study collected up to eight years after randomisation. An additional analysis was performed including only those patients originally randomised to receive early subcutaneous interferon (IFN) β-1a (n = 259). Baseline/prestudy variables, indicators of early clinical and MRI activity (baseline to month 24), and indicators of IFN β-1a treatment exposure (including medication possession ratio (MPR)) were investigated as candidate prognostic factors for outcomes measured from baseline and from month 24 to LTFU. Explanatory variables identified from univariate regression models (p ≤ 0.15) were selected for inclusion in stepwise multiple regression models.

Results: Candidate prognostic factors selected by the univariate analysis (p ≤ 0.15) included age, MS duration, baseline brain volume, EDSS score, and log(T2 burden of disease (BOD)). In most of the multivariate regression models applied, higher baseline brain volume and MPR predicted better long-term clinical outcomes, while higher baseline and greater early increase in EDSS score predicted worse outcomes.

Conclusion: Identification of markers that may be prognostic for long-term disability could help identify MS patients at higher risk of disability progression.

Citation

Traboulsee, A. L., Cornelisse, P., Sandberg-Wollheim, M., Uitdehaag, B. M., Kappos, L., Jongen, P. J., Constantinescu, C. S., Verdun di Cantogno, E., & Li, D. K. (2016). Prognostic factors for long-term outcomes in relapsing–remitting multiple sclerosis. Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2, https://doi.org/10.1177/2055217316666406

• Journal Article Type: Article
• Acceptance Date: Aug 5, 2016
• Online Publication Date: Sep 6, 2016
• Publication Date: 2016-01
• Deposit Date: Oct 19, 2016
• Publicly Available Date: Oct 19, 2016
• Journal: Multiple Sclerosis Journal – Experimental, Translational and Clinical
• Electronic ISSN: 2055-2173
• Publisher: SAGE Publications
• Peer Reviewed: Peer Reviewed
• Volume: 2
• DOI: https://doi.org/10.1177/2055217316666406
• Keywords: Disability, MRI, Long-term outcomes, Multiple sclerosis, Prognosis
• Public URL: https://nottingham-repository.worktribe.com/output/819107
• Publisher URL: https://journals.sagepub.com/doi/10.1177/2055217316666406
• Contract Date: Oct 19, 2016