International criteria for acute kidney injury: advantages and remaining challenges

Selby, Nicholas M.; Fluck, Richard J.; Kolhe, Nitin V.; Taal, Maarten W.

Abstract

• Acute Kidney Injury (AKI) is defined using widely accepted international criteria that are based on changes in serum creatinine concentration and degree of oliguria.
• AKI, when defined in this way, has a strong association with poor patient outcomes, including high mortality rates and longer hospital admissions with increased resource utilisation and subsequent chronic kidney disease.
• The detection of AKI using current criteria can assist with AKI diagnosis and stratification of individual patient risk.
• The diagnosis of AKI requires clinical judgement to integrate the definition of AKI with the clinical situation, to determine underlying cause of AKI, and to take account of factors that may affect performance of current definitions.

• Journal Article Type: Article
• Acceptance Date: Sep 13, 2016
• Publication Date: Sep 13, 2016
• Deposit Date: Jan 27, 2017
• Publicly Available Date: Jan 27, 2017
• Journal: PLOS Medicine
• Print ISSN: 1549-1277
• Electronic ISSN: 1549-1676
• Publisher: Public Library of Science
• Peer Reviewed: Peer Reviewed
• Volume: 13
• Issue: 9
• Article Number: e1002122
• DOI: https://doi.org/10.1371/journal.pmed.1002122
• Keywords: AKI, acute kidney injury; CKD, chronic kidney disease; GFR, glomerular filtration rate; KDIGO, Kidney Disease: Improving Global Outcomes; LMICs, low- and middle-income countries; RRT, renal replacement therapy
• Public URL: https://nottingham-repository.worktribe.com/output/818195
• Publisher URL: http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002122