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International criteria for acute kidney injury: advantages and remaining challenges

Selby, Nicholas M.; Fluck, Richard J.; Kolhe, Nitin V.; Taal, Maarten W.

Authors

Richard J. Fluck

Nitin V. Kolhe

Maarten W. Taal



Abstract

• Acute Kidney Injury (AKI) is defined using widely accepted international criteria that are based on changes in serum creatinine concentration and degree of oliguria.
• AKI, when defined in this way, has a strong association with poor patient outcomes, including high mortality rates and longer hospital admissions with increased resource utilisation and subsequent chronic kidney disease.
• The detection of AKI using current criteria can assist with AKI diagnosis and stratification of individual patient risk.
• The diagnosis of AKI requires clinical judgement to integrate the definition of AKI with the clinical situation, to determine underlying cause of AKI, and to take account of factors that may affect performance of current definitions.

Citation

Selby, N. M., Fluck, R. J., Kolhe, N. V., & Taal, M. W. (2016). International criteria for acute kidney injury: advantages and remaining challenges. PLoS Medicine, 13(9), https://doi.org/10.1371/journal.pmed.1002122

Journal Article Type Article
Acceptance Date Sep 13, 2016
Publication Date Sep 13, 2016
Deposit Date Jan 27, 2017
Publicly Available Date Jan 27, 2017
Journal PLOS Medicine
Print ISSN 1549-1277
Electronic ISSN 1549-1676
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 13
Issue 9
Article Number e1002122
DOI https://doi.org/10.1371/journal.pmed.1002122
Keywords AKI, acute kidney injury; CKD, chronic kidney disease; GFR, glomerular filtration rate; KDIGO, Kidney Disease: Improving Global Outcomes; LMICs, low- and middle-income countries; RRT, renal replacement therapy
Public URL http://eprints.nottingham.ac.uk/id/eprint/40149
Publisher URL http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002122
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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