Relative efficacy of topical non-steroidal anti-inflammatory drugs and topical capsaicin in osteoarthritis: protocol for an individual patient data meta-analysis

Persson, Monica S.M.; Fu, Yu; Bhattacharya, Archan; Goh, Siew-Li; Middelkoop, Marienke van; Bierma-Zeinstra, Sita M.A.; Walsh, David A.; Doherty, Michael; Zhang, Weiya

Abstract

Background

Pain is the most troubling issue to patients with osteoarthritis (OA), yet current pharmacological treatments offer only small-to-moderate pain reduction. Current guidelines therefore emphasise the need to identify predictors of treatment response. In line with these recommendations, an individual patient data (IPD) meta-analysis will be conducted. The study aims to investigate the relative treatment effects of topical non-steroidal anti-inflammatory drugs (NSAIDs) and topical capsaicin in OA and to identify patient-level predictors of treatment response.

Methods

IPD will be collected from randomised controlled trials (RCTs) of topical NSAIDs and capsaicin in OA. Multilevel regression modelling will be conducted to determine predictors for the specific and the overall treatment effect.

Discussion

Through the identification of treatment responders, this IPD meta-analysis may improve the current understanding of the pain mechanisms in OA and guide clinical decision-making. Identifying and prescribing the treatment most likely to be beneficial for an individual with OA will improve the efficiency of patient management.

Citation

Persson, M. S., Fu, Y., Bhattacharya, A., Goh, S.-L., Middelkoop, M. V., Bierma-Zeinstra, S. M., Walsh, D. A., Doherty, M., & Zhang, W. (2016). Relative efficacy of topical non-steroidal anti-inflammatory drugs and topical capsaicin in osteoarthritis: protocol for an individual patient data meta-analysis. Systematic Reviews, 5(1), Article 165. https://doi.org/10.1186/s13643-016-0348-8

• Journal Article Type: Article
• Acceptance Date: Sep 21, 2016
• Online Publication Date: Sep 29, 2016
• Publication Date: Sep 29, 2016
• Deposit Date: Jan 13, 2017
• Publicly Available Date: Jan 13, 2017
• Journal: Systematic Reviews
• Electronic ISSN: 2046-4053
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 5
• Issue: 1
• Article Number: 165
• DOI: https://doi.org/10.1186/s13643-016-0348-8
• Keywords: Osteoarthritis, Topical, NSAIDs, Capsaicin, Individual patient data meta-analysis
• Public URL: https://nottingham-repository.worktribe.com/output/808907
• Publisher URL: http://dx.doi.org/10.1186/s13643-016-0348-8
• Contract Date: Jan 13, 2017