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Relative efficacy of topical non-steroidal anti-inflammatory drugs and topical capsaicin in osteoarthritis: protocol for an individual patient data meta-analysis

Persson, Monica S.M.; Fu, Yu; Bhattacharya, Archan; Goh, Siew-Li; Middelkoop, Marienke van; Bierma-Zeinstra, Sita M.A.; Walsh, David A.; Doherty, Michael; Zhang, Weiya

Authors

Monica S.M. Persson

Yu Fu

Archan Bhattacharya

Siew-Li Goh

Marienke van Middelkoop

Sita M.A. Bierma-Zeinstra

David A. Walsh

Michael Doherty



Abstract

Background

Pain is the most troubling issue to patients with osteoarthritis (OA), yet current pharmacological treatments offer only small-to-moderate pain reduction. Current guidelines therefore emphasise the need to identify predictors of treatment response. In line with these recommendations, an individual patient data (IPD) meta-analysis will be conducted. The study aims to investigate the relative treatment effects of topical non-steroidal anti-inflammatory drugs (NSAIDs) and topical capsaicin in OA and to identify patient-level predictors of treatment response.

Methods

IPD will be collected from randomised controlled trials (RCTs) of topical NSAIDs and capsaicin in OA. Multilevel regression modelling will be conducted to determine predictors for the specific and the overall treatment effect.

Discussion

Through the identification of treatment responders, this IPD meta-analysis may improve the current understanding of the pain mechanisms in OA and guide clinical decision-making. Identifying and prescribing the treatment most likely to be beneficial for an individual with OA will improve the efficiency of patient management.

Citation

Persson, M. S., Fu, Y., Bhattacharya, A., Goh, S., Middelkoop, M. V., Bierma-Zeinstra, S. M., …Zhang, W. (2016). Relative efficacy of topical non-steroidal anti-inflammatory drugs and topical capsaicin in osteoarthritis: protocol for an individual patient data meta-analysis. Systematic Reviews, 5(1), Article 165. https://doi.org/10.1186/s13643-016-0348-8

Journal Article Type Article
Acceptance Date Sep 21, 2016
Online Publication Date Sep 29, 2016
Publication Date Sep 29, 2016
Deposit Date Jan 13, 2017
Publicly Available Date Mar 28, 2024
Journal Systematic Reviews
Electronic ISSN 2046-4053
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 5
Issue 1
Article Number 165
DOI https://doi.org/10.1186/s13643-016-0348-8
Keywords Osteoarthritis, Topical, NSAIDs, Capsaicin, Individual patient data meta-analysis
Public URL https://nottingham-repository.worktribe.com/output/808907
Publisher URL http://dx.doi.org/10.1186/s13643-016-0348-8

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