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IL-36 receptor is expressed by human blood and intestinal T lymphocytes and is dose–dependently activated via IL-36β and induces CD4+ lymphocyte proliferation

Penha, Rafael; Higgins, John; Mutamba, Shilla; Barrow, Paul; Mahida, Yashwant R.; Foster, Neil

Authors

Rafael Penha

John Higgins

Shilla Mutamba

Paul Barrow

Yashwant R. Mahida

Neil Foster



Abstract

We show that IL-36R is expressed by T (CD4+ and CD8+) and B (CD19+) lymphocytes in human blood and also by CD4+ T lymphocytes in the intestinal lamina propria. IL-36R protein was mostly stored in the cytoplasm of CD4 lymphocytes and B cells, during steady state conditions and the greatest expression of IL-36R mRNA was measured in CD4+ (T helper) lymphocytes. IL-36 β, which functions via IL-36R induced rapid and significant (P < 0.05) proliferation of CD4+ lymphocytes, within 48 h. IL-36R expression was also maintained on the surface of circulating CD4+ lymphocytes which enter the intestinal lamina propria.

In conclusion our study is the first to show that (1) all human blood lymphocytes express IL-36R; (2) IL-36R expression is maintained by circulating CD4+ lymphocytes which enter the intestinal lamina propria and (3) IL-36R/IL-36 β induces rapid CD4 lymphocyte proliferation. The possible significance of these results in the context of human disease is discussed.

Citation

Penha, R., Higgins, J., Mutamba, S., Barrow, P., Mahida, Y. R., & Foster, N. (2016). IL-36 receptor is expressed by human blood and intestinal T lymphocytes and is dose–dependently activated via IL-36β and induces CD4+ lymphocyte proliferation. Cytokine, 85, https://doi.org/10.1016/j.cyto.2016.05.023

Journal Article Type Article
Acceptance Date May 24, 2016
Online Publication Date Jun 4, 2016
Publication Date Sep 30, 2016
Deposit Date Mar 27, 2017
Publicly Available Date Mar 27, 2017
Journal Cytokine
Print ISSN 1043-4666
Electronic ISSN 1096-0023
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 85
DOI https://doi.org/10.1016/j.cyto.2016.05.023
Keywords IL-36; IL-36R; Human; Lymphocyte
Public URL http://eprints.nottingham.ac.uk/id/eprint/41582
Publisher URL https://doi.org/10.1016/j.cyto.2016.05.023
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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