Detection of a Yersinia pestisgene homologue in rodent samples

Giles, Timothy A.; Greenwood, Alex D.; Tsangaras, Kyriakos; Giles, Tom C.; Barrow, Paul A.; Hannant, Duncan; Abu-Median, Abu-Bakr; Yon, Lisa

Abstract

A homologue to a widely used genetic marker, pla, for Yersinia pestis has been identified in tissue samples of two species of rat (Rattus rattus and Rattus norvegicus) and of mice (Mus musculus and Apodemus sylvaticus) using a microarray based platform to screen for zoonotic pathogens of interest. Samples were from urban locations in the UK (Liverpool) and Canada (Vancouver). The results indicate the presence of an unknown bacterium that shares a homologue for the pla gene of Yersinia pestis, so caution should be taken when using this gene as a diagnostic marker.

Citation

Giles, T. A., Greenwood, A. D., Tsangaras, K., Giles, T. C., Barrow, P. A., Hannant, D., Abu-Median, A.-B., & Yon, L. (2016). Detection of a Yersinia pestisgene homologue in rodent samples. PeerJ, 4, Article e2216. https://doi.org/10.7717/peerj.2216

• Journal Article Type: Article
• Acceptance Date: Jun 14, 2016
• Publication Date: Aug 17, 2016
• Deposit Date: Oct 31, 2016
• Publicly Available Date: Oct 31, 2016
• Journal: PeerJ
• Electronic ISSN: 2167-8359
• Publisher: PeerJ
• Peer Reviewed: Peer Reviewed
• Volume: 4
• Article Number: e2216
• DOI: https://doi.org/10.7717/peerj.2216
• Keywords: Yersinia pestis, Rodents, Screening, Microarray
• Public URL: https://nottingham-repository.worktribe.com/output/805359
• Publisher URL: https://peerj.com/articles/2216/
• Contract Date: Oct 31, 2016