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Detection of a Yersinia pestisgene homologue in rodent samples

Giles, Timothy A.; Greenwood, Alex D.; Tsangaras, Kyriakos; Giles, Tom C.; Barrow, Paul A.; Hannant, Duncan; Abu-Median, Abu-Bakr; Yon, Lisa

Authors

Timothy A. Giles

Alex D. Greenwood

Kyriakos Tsangaras

Tom C. Giles

Paul A. Barrow

Duncan Hannant

Abu-Bakr Abu-Median

LISA YON lisa.yon@nottingham.ac.uk
Associate Professor



Abstract

A homologue to a widely used genetic marker, pla, for Yersinia pestis has been identified in tissue samples of two species of rat (Rattus rattus and Rattus norvegicus) and of mice (Mus musculus and Apodemus sylvaticus) using a microarray based platform to screen for zoonotic pathogens of interest. Samples were from urban locations in the UK (Liverpool) and Canada (Vancouver). The results indicate the presence of an unknown bacterium that shares a homologue for the pla gene of Yersinia pestis, so caution should be taken when using this gene as a diagnostic marker.

Citation

Giles, T. A., Greenwood, A. D., Tsangaras, K., Giles, T. C., Barrow, P. A., Hannant, D., …Yon, L. (2016). Detection of a Yersinia pestisgene homologue in rodent samples. PeerJ, 4, https://doi.org/10.7717/peerj.2216

Journal Article Type Article
Acceptance Date Jun 14, 2016
Publication Date Aug 17, 2016
Deposit Date Oct 31, 2016
Publicly Available Date Oct 31, 2016
Journal PeerJ
Electronic ISSN 2167-8359
Publisher PeerJ
Peer Reviewed Peer Reviewed
Volume 4
Article Number e2216
DOI https://doi.org/10.7717/peerj.2216
Keywords Yersinia pestis, Rodents, Screening, Microarray
Public URL http://eprints.nottingham.ac.uk/id/eprint/38074
Publisher URL https://peerj.com/articles/2216/
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

Files

Accepted 14 06 2016 Hannant D Yersinia Pestis peerj-04-2216.pdf (375 Kb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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