Skip to main content

Research Repository

Advanced Search

Gene pathway development in human epicardial adipose tissue during early life

Ojha, Shalini; Fainberg, Hernan P.; Wilson, Victoria; Pelella, Giuseppe; Castellanos, Marcos; May, Sean; Lotto, Attilio A.; Sacks, Harold; Symonds, Michael E.; Budge, Helen

Gene pathway development in human epicardial adipose tissue during early life Thumbnail


Authors

SHALINI OJHA Shalini.Ojha@nottingham.ac.uk
Professor of Neonatal Medicine

Hernan P. Fainberg

Victoria Wilson

Giuseppe Pelella

Marcos Castellanos

Attilio A. Lotto

Harold Sacks

Michael E. Symonds

HELEN BUDGE HELEN.BUDGE@NOTTINGHAM.AC.UK
Professor of Neonatal Medicine



Abstract

Studies in rodents and newborn humans demonstrate the influence of brown adipose tissue (BAT) in temperature control and energy balance and a critical role in the regulation of body weight. Here, we obtained samples of epicardial adipose tissue (EAT) from neonates, infants, and children in order to evaluate changes in their transcriptional landscape by applying a systems biology approach. Surprisingly, these analyses revealed that the transition to infancy is a critical stage for changes in the morphology of EAT and is reflected in unique gene expression patterns of a substantial proportion of thermogenic gene transcripts (~10%). Our results also indicated that the pattern of gene expression represents a distinct developmental stage, even after the rebound in abundance of thermogenic genes in later childhood. Using weighted gene coexpression network analyses, we found precise anthropometric-specific correlations with changes in gene expression and the decline of thermogenic capacity within EAT. In addition, these results indicate a sequential order of transcriptional events affecting cellular pathways, which could potentially explain the variation in the amount, or activity, of BAT in adulthood. Together, these results provide a resource to elucidate gene regulatory mechanisms underlying the progressive development of BAT during early life.

Journal Article Type Article
Acceptance Date Jul 15, 2016
Online Publication Date Aug 18, 2016
Deposit Date Oct 18, 2016
Publicly Available Date Oct 18, 2016
Journal JCI Insight
Electronic ISSN 2379-3708
Peer Reviewed Peer Reviewed
Volume 1
Issue 13
Article Number e87460
DOI https://doi.org/10.1172/jci.insight.87460
Public URL https://nottingham-repository.worktribe.com/output/805200
Publisher URL https://insight.jci.org/articles/view/87460

Files






You might also like



Downloadable Citations