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New Found Hope for Antibiotic Discovery: Lipid II Inhibitors

Ng, Vivian; Chan, Weng C.

Authors

Vivian Ng

Weng C. Chan



Abstract

Research into antibacterial agents has recently gathered pace in light of the disturbing crisis of antimicrobial resistance. The development of modern tools offers the opportunity of reviving the fallen era of antibacterial discovery through uncovering novel lead compounds that target vital bacterial cell components, such as lipid II. This paper provides a summary of the role of lipid II as well as an overview and insight into the structural features of macrocyclic peptides that inhibit this bacterial cell wall component. The recent discovery of teixobactin, a new class of lipid II inhibitor has generated substantial research interests. As such, the significant progress that has been achieved towards its development as a promising antibacterial agent is discussed.

Citation

Ng, V., & Chan, W. C. (2016). New Found Hope for Antibiotic Discovery: Lipid II Inhibitors. Chemistry - A European Journal, 22(36), 12606-12616. https://doi.org/10.1002/chem.201601315

Journal Article Type Article
Acceptance Date May 19, 2016
Online Publication Date Jul 8, 2016
Publication Date Aug 26, 2016
Deposit Date Oct 14, 2016
Publicly Available Date Oct 14, 2016
Journal Chemistry - A European Journal
Print ISSN 0947-6539
Electronic ISSN 1521-3765
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 22
Issue 36
Pages 12606-12616
DOI https://doi.org/10.1002/chem.201601315
Keywords antibiotics; lipid II inhibitors; macrocyclic peptides; mannopeptimycin; teixobactin
Public URL http://eprints.nottingham.ac.uk/id/eprint/37576
Publisher URL http://onlinelibrary.wiley.com/doi/10.1002/chem.201601315/abstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf
Additional Information This is the peer reviewed version of the following article: V. Ng, W. C. Chan, Chem. Eur. J. 2016, 22, 12606, which has been published in final form at http://dx.doi.org/10.1002/chem.201601315. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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