New Found Hope for Antibiotic Discovery: Lipid II Inhibitors

Ng, Vivian; Chan, Weng C.

Abstract

Research into antibacterial agents has recently gathered pace in light of the disturbing crisis of antimicrobial resistance. The development of modern tools offers the opportunity of reviving the fallen era of antibacterial discovery through uncovering novel lead compounds that target vital bacterial cell components, such as lipid II. This paper provides a summary of the role of lipid II as well as an overview and insight into the structural features of macrocyclic peptides that inhibit this bacterial cell wall component. The recent discovery of teixobactin, a new class of lipid II inhibitor has generated substantial research interests. As such, the significant progress that has been achieved towards its development as a promising antibacterial agent is discussed.

Citation

Ng, V., & Chan, W. C. (2016). New Found Hope for Antibiotic Discovery: Lipid II Inhibitors. Chemistry - A European Journal, 22(36), 12606-12616. https://doi.org/10.1002/chem.201601315

• Journal Article Type: Article
• Acceptance Date: May 19, 2016
• Online Publication Date: Jul 8, 2016
• Publication Date: Aug 26, 2016
• Deposit Date: Oct 14, 2016
• Publicly Available Date: Oct 14, 2016
• Journal: Chemistry - A European Journal
• Print ISSN: 0947-6539
• Electronic ISSN: 1521-3765
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 22
• Issue: 36
• Pages: 12606-12616
• DOI: https://doi.org/10.1002/chem.201601315
• Keywords: antibiotics; lipid II inhibitors; macrocyclic peptides; mannopeptimycin; teixobactin
• Public URL: https://nottingham-repository.worktribe.com/output/804401
• Publisher URL: http://onlinelibrary.wiley.com/doi/10.1002/chem.201601315/abstract
• Additional Information: This is the peer reviewed version of the following article: V. Ng, W. C. Chan, Chem. Eur. J. 2016, 22, 12606, which has been published in final form at http://dx.doi.org/10.1002/chem.201601315. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
• Contract Date: Oct 14, 2016