Gene × environment interactions in schizophrenia: evidence from genetic mouse models

Moran, Paula M.; Stokes, Jennifer; Marr, Julia; Bock, Gavin; Desbonnet, Lieve; Waddington, J.L.; O'Tuathaigh, C.M.P.

Abstract

The study of gene × environment, as well as epistatic interactions in schizophrenia, has provided important insight into the complex etiopathologic basis of schizophrenia. It has also increased our understanding of the role of susceptibility genes in the disorder and is an important consideration as we seek to translate genetic advances into novel antipsychotic treatment targets. This review summarises data arising from research involving the modelling of gene × environment interactions in schizophrenia using preclinical genetic models. Evidence for synergistic effects on the expression of schizophrenia-relevant endophenotypes will be discussed. It is proposed that valid and multifactorial preclinical models are important tools for identifying critical areas, as well as underlying mechanisms, of convergence of genetic and environmental risk factors, and their interaction in schizophrenia.

Citation

Moran, P. M., Stokes, J., Marr, J., Bock, G., Desbonnet, L., Waddington, J., & O'Tuathaigh, C. (2016). Gene × environment interactions in schizophrenia: evidence from genetic mouse models. Neural Plasticity, 2016, 1-23. https://doi.org/10.1155/2016/2173748

• Journal Article Type: Article
• Acceptance Date: Aug 21, 2016
• Publication Date: Aug 31, 2016
• Deposit Date: Jul 31, 2017
• Publicly Available Date: Jul 31, 2017
• Journal: Neural Plasticity
• Print ISSN: 2090-5904
• Electronic ISSN: 1687-5443
• Publisher: Hindawi
• Peer Reviewed: Peer Reviewed
• Volume: 2016
• Article Number: 2173748
• Pages: 1-23
• DOI: https://doi.org/10.1155/2016/2173748
• Public URL: https://nottingham-repository.worktribe.com/output/803825
• Publisher URL: https://www.hindawi.com/journals/np/2016/2173748/
• Contract Date: Jul 31, 2017