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A heavy metal P-type ATPase OsHMA4 prevents copper accumulation in rice grain

Huang, Xin-Yuan; Deng, Fenglin; Yamaji, Naoki; Pinson, Shannon R.M..; Fujii-Kashino, Miho; Danku, John; Douglas, Alex; Guerinot, Mary Lou; Salt, David E.; Ma, Jian Feng

Authors

Xin-Yuan Huang

Fenglin Deng

Naoki Yamaji

Shannon R.M.. Pinson

Miho Fujii-Kashino

John Danku

Alex Douglas

Mary Lou Guerinot

David E. Salt

Jian Feng Ma



Abstract

Rice is a major source of calories and mineral nutrients for over half the world’s human population. However, little is known in rice about the genetic basis of variation in accumulation of copper (Cu), an essential but potentially toxic nutrient. Here we identify OsHMA4 as the likely causal gene of a quantitative trait locus controlling Cu accumulation in rice grain. We provide evidence that OsHMA4 functions to sequester Cu into root vacuoles, limiting Cu accumulation in the grain. The difference in grain Cu accumulation is most likely attributed to a single amino acid substitution that leads to different OsHMA4 transport activity. The allele associated with low grain Cu was found in 67 of the 1,367 rice accessions investigated. Identification of natural allelic variation in OsHMA4 may facilitate the development of rice varieties with grain Cu concentrations tuned to both the concentration of Cu in the soil and dietary needs.

Citation

Huang, X., Deng, F., Yamaji, N., Pinson, S. R., Fujii-Kashino, M., Danku, J., …Ma, J. F. (2016). A heavy metal P-type ATPase OsHMA4 prevents copper accumulation in rice grain. Nature Communications, 7(12138), https://doi.org/10.1038/ncomms12138

Journal Article Type Article
Acceptance Date Jun 3, 2016
Online Publication Date Jul 8, 2016
Publication Date Jul 8, 2016
Deposit Date Oct 11, 2016
Publicly Available Date Nov 18, 2016
Journal Nature Communications
Electronic ISSN 2041-1723
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 7
Issue 12138
DOI https://doi.org/10.1038/ncomms12138
Public URL http://eprints.nottingham.ac.uk/id/eprint/37471
Publisher URL http://www.nature.com/articles/ncomms12138
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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