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The Insulin Resistance Intervention after Stroke trial: a perspective on future practice and research

Bath, Philip M.W.; Appleton, Jason P.; Sprigg, Nikola

Authors

PHILIP BATH philip.bath@nottingham.ac.uk
Stroke Association Professor of Stroke Medicine

Jason P. Appleton

NIKOLA SPRIGG nikola.sprigg@nottingham.ac.uk
Professor of Stroke Medicine



Abstract

The prevention of recurrent events after ischaemic stroke and transient ischaemic attack is well established and based on lifestyle changes, antithrombotics, statins, antihypertensives and carotid surgery. The international IRIS trial assessed whether pioglitazone, a glucose-lowering insulin-sensitizing drug, would reduce recurrent vascular events in patients with ischaemic stroke or transient ischaemic attack. After 4.8 years, pioglitazone therapy was associated with reduced vascular events and new diabetes, and an increase in weight, oedema and bone fractures. Pioglitazone may add to the strategies for preventing further events in patients with stroke or transient ischaemic attack.

Citation

Bath, P. M., Appleton, J. P., & Sprigg, N. (in press). The Insulin Resistance Intervention after Stroke trial: a perspective on future practice and research. International Journal of Stroke, https://doi.org/10.1177/1747493016660099

Journal Article Type Article
Acceptance Date May 30, 2016
Online Publication Date Jul 12, 2016
Deposit Date Jul 28, 2016
Publicly Available Date Jul 28, 2016
Journal International Journal of Stroke
Print ISSN 1747-4930
Electronic ISSN 1747-4949
Publisher SAGE Publications
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1177/1747493016660099
Keywords Prevention, Ischaemic Stroke, Clinical Trial, Stroke, Treatment, Vascular Events
Public URL http://eprints.nottingham.ac.uk/id/eprint/35498
Publisher URL http://wso.sagepub.com/content/early/2016/07/12/1747493016660099
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

Files

IRIS editorial accepted manuscript 20160329.pdf (104 Kb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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