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A new generation of smart amine donors for transaminase-mediated biotransformations

Gomm, Andrew; Lewis, William; Green, Anthony P.; O'Reilly, Elaine

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Authors

Andrew Gomm

William Lewis

Anthony P. Green

Elaine O'Reilly



Abstract

The application of ω-transaminase biocatalysts for the synthesis of optically pure chiral amines presents a number of challenges, including difficulties associated with displacing the challenging reaction equilibria. Herein, we report a highly effective approach using low equivalents of the novel diamine donor, cadaverine, which enables high conversions of challenging substrates to the corresponding chiral amines in excellent ee. This approach paves the way for the design of self-sufficient fermentation processes combining transaminase biotransformations with existing strategies for cadaverine production via decarboxylation of endogenous lysine.

Citation

Gomm, A., Lewis, W., Green, A. P., & O'Reilly, E. (2016). A new generation of smart amine donors for transaminase-mediated biotransformations. Chemistry - A European Journal, 22(36), 12692-12695. https://doi.org/10.1002/chem.201603188

Journal Article Type Article
Acceptance Date Jul 11, 2016
Publication Date Jul 14, 2016
Deposit Date Jul 22, 2016
Publicly Available Date Jul 22, 2016
Journal Chemistry - a European Journal
Print ISSN 0947-6539
Electronic ISSN 1521-3765
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 22
Issue 36
Pages 12692-12695
DOI https://doi.org/10.1002/chem.201603188
Keywords asymmetric catalysis, biocatalysis, chiral amine, diamine, transaminase
Public URL https://nottingham-repository.worktribe.com/output/800997
Publisher URL http://onlinelibrary.wiley.com/doi/10.1002/chem.201603188/abstract
Related Public URLs http://onlinelibrary.wiley.com/doi/10.1002/chem.201603188/abstract
Additional Information This is the peer reviewed version of the following article: Gomm, A., Lewis, W., Green, A.P. and O'Reilly, E. (2016), A new generation of smart amine donors for transaminase-mediated biotransformations. Chem. Eur. J., which has been published in final form at doi:10.1002/chem.201603188. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

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