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METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: an initiative of the Joint Programme for Neurodegenerative Disease Research

Dichgans, Martin; Wardlaw, Joanna; Smith, Eric; Zietemann, Vera; Seshadri, Sudha; Sachdev, Perminder; Biessels, Geert Jan; Fazekas, Franz; Benavente, Oscar; Pantoni, Leonardo; De Leeuw, Frank-Erik; Norrving, Bo; Matthews, Paul; Chen, Christopher; Mok, Vincent; Düring, Marco; Whiteley, Will; Shuler, Kirsten; Alonso, Alvaro; Black, Sandra E.; Brayne, Carol; Chabriat, Hugues; Cordonnier, Charlotte; Doubal, Fergus; Duzel, Emrah; Ewers, Michael; Frayne, Richard; Hachinski, Vladimir; Ikram, Mohammad Arfan; Jessen, Frank; Jouvent, Eric; Linn, Jennifer; O'Brien, John; van Oostenbrugge, Robert; Malik, Rainer; Mazoyer, Bernard; Schmidt, Reinhold; Sposato, Luciano A.; Stephan, Blossom; Swartz, Richard H.; Vernooij, Meike; Viswanathan, Anand; Werring, David; Abe, Koji; Allan, Louise; Arba, Francesco; Diener, H.-C.; Davis, S.; Hankey, G.; Lees, K.R.; Ovbiagele, B.; Weir, C.; Bae, Hee-Joon; Bath, Philip M.W.; Bordet, Regis; Breteler, Monique; Choi, Seong; Deary, Ian; DeCarli, Charles; Ebmeier, Klaus; Feng, Lei; Greenberg, Steven M.; Ihara, Masafumi; Kalaria, Rajesh; Kim, SanYun; Lim, Jae-Sung; Lindley, Richard I.; Mead, Gillian; Murray, Alison; Quinn, Terry; Ritchie, Craig; Sacco, Ralph; Al-Shahi Salman, Rustam; Sprigg, Nikola; Sudlow, Cathie; Thomas, Alan; van Boxtel, Martin; van der Grond, Jeroen; van der Lugt, Aad; Yang, Yuan-Han


Martin Dichgans

Joanna Wardlaw

Eric Smith

Vera Zietemann

Sudha Seshadri

Perminder Sachdev

Geert Jan Biessels

Franz Fazekas

Oscar Benavente

Leonardo Pantoni

Frank-Erik De Leeuw

Bo Norrving

Paul Matthews

Christopher Chen

Vincent Mok

Marco Düring

Will Whiteley

Kirsten Shuler

Alvaro Alonso

Sandra E. Black

Carol Brayne

Hugues Chabriat

Charlotte Cordonnier

Fergus Doubal

Emrah Duzel

Michael Ewers

Richard Frayne

Vladimir Hachinski

Mohammad Arfan Ikram

Frank Jessen

Eric Jouvent

Jennifer Linn

John O'Brien

Robert van Oostenbrugge

Rainer Malik

Bernard Mazoyer

Reinhold Schmidt

Luciano A. Sposato

Blossom Stephan

Richard H. Swartz

Meike Vernooij

Anand Viswanathan

David Werring

Koji Abe

Louise Allan

Francesco Arba

H.-C. Diener

S. Davis

G. Hankey

K.R. Lees

B. Ovbiagele

C. Weir

Hee-Joon Bae

Philip M.W. Bath

Regis Bordet

Monique Breteler

Seong Choi

Ian Deary

Charles DeCarli

Klaus Ebmeier

Lei Feng

Steven M. Greenberg

Masafumi Ihara

Rajesh Kalaria

SanYun Kim

Jae-Sung Lim

Richard I. Lindley

Gillian Mead

Alison Murray

Terry Quinn

Craig Ritchie

Ralph Sacco

Rustam Al-Shahi Salman

Professor of Stroke Medicine

Cathie Sudlow

Alan Thomas

Martin van Boxtel

Jeroen van der Grond

Aad van der Lugt

Yuan-Han Yang


Dementia is a global problem and major target for health care providers. Although up to 45% of cases are primarily or partly due to cerebrovascular disease, little is known of these mechanisms or treatments because most dementia research still focuses on pure Alzheimer's disease. An improved understanding of the vascular contributions to neurodegeneration and dementia, particularly by small vessel disease, is hampered by imprecise data, including the incidence and prevalence of symptomatic and clinically “silent” cerebrovascular disease, long-term outcomes (cognitive, stroke, or functional), and risk factors. New large collaborative studies with long follow-up are expensive and time consuming, yet substantial data to advance the field are available. In an initiative funded by the Joint Programme for Neurodegenerative Disease Research, 55 international experts surveyed and assessed available data, starting with European cohorts, to promote data sharing to advance understanding of how vascular disease affects brain structure and function, optimize methods for cerebrovascular disease in neurodegeneration research, and focus future research on gaps in knowledge. Here, we summarize the results and recommendations from this initiative. We identified data from over 90 studies, including over 660,000 participants, many being additional to neurodegeneration data initiatives. The enthusiastic response means that cohorts from North America, Australasia, and the Asia Pacific Region are included, creating a truly global, collaborative, data sharing platform, linked to major national dementia initiatives. Furthermore, the revised World Health Organization International Classification of Diseases version 11 should facilitate recognition of vascular-related brain damage by creating one category for all cerebrovascular disease presentations and thus accelerate identification of targets for dementia prevention.


Dichgans, M., Wardlaw, J., Smith, E., Zietemann, V., Seshadri, S., Sachdev, P., …Yang, Y. (in press). METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: an initiative of the Joint Programme for Neurodegenerative Disease Research. Alzheimer's and Dementia,

Journal Article Type Article
Acceptance Date Jun 10, 2016
Online Publication Date Aug 1, 2016
Deposit Date Sep 30, 2016
Publicly Available Date Sep 30, 2016
Journal Alzheimer's & Dementia
Electronic ISSN 1552-5260
Publisher Elsevier
Peer Reviewed Peer Reviewed
Keywords Dementia; Cerebrovascular disease; Small vessel disease; Neurodegeneration, Cohorts, Survey
Public URL
Publisher URL
Copyright Statement Copyright information regarding this work can be found at the following address:


Metacohorts 20160623.pdf (1.1 Mb)

Copyright Statement
Copyright information regarding this work can be found at the following address:

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