The multidrug transporter ABCG2: still more questions than answers

Horsey, Aaron J.; Cox, Megan H.; Sarwat, Sunehera; Kerr, Ian D.

Abstract

ABCG2 is one of at least three human ATP binding cassette (ABC) transporters which can facilitate the export from cells of a wide range of chemically unrelated drug molecules. This capacity for multidrug transport is not only a confounding factor in chemotherapy, but is also one of the more perplexing phenomena in transporter biochemistry. Since its discovery in the last decade of the 20th century much has been revealed about ABCG2's localization, physiological function and its broad substrate range. There have also been many investigations of its structure and molecular mechanism. In this mini review article we take a Rumsfeldian approach to ABCG2 and essentially ask what we do know about this transporter, and what we will need to know about this transporter if we wish to use modulation of ABCG2 activity as a therapeutic approach.

Citation

Horsey, A. J., Cox, M. H., Sarwat, S., & Kerr, I. D. (2016). The multidrug transporter ABCG2: still more questions than answers. Biochemical Society Transactions, 44(3), 824-830. https://doi.org/10.1042/BST20160014

• Journal Article Type: Article
• Conference Name: Biochemical Society: Membrane Proteins from Amino Acids to Zinc: A commemoration of the life and work of Prof. Stephen Baldwin
• Acceptance Date: Mar 21, 2016
• Online Publication Date: Jun 9, 2016
• Publication Date: Jun 15, 2016
• Deposit Date: Jun 21, 2016
• Publicly Available Date: Jun 21, 2016
• Journal: Biochemical Society Transactions
• Print ISSN: 0300-5127
• Electronic ISSN: 0300-5127
• Publisher: Portland Press
• Peer Reviewed: Peer Reviewed
• Volume: 44
• Issue: 3
• Pages: 824-830
• DOI: https://doi.org/10.1042/BST20160014
• Public URL: https://nottingham-repository.worktribe.com/output/794966
• Publisher URL: http://www.biochemsoctrans.org/content/44/3/824
• Additional Information: The final version of record is available at http://www.biochemsoctrans.org/content/44/3/824