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The multidrug transporter ABCG2: still more questions than answers

Horsey, Aaron J.; Cox, Megan H.; Sarwat, Sunehera; Kerr, Ian D.

Authors

Aaron J. Horsey

Megan H. Cox

Sunehera Sarwat

Ian D. Kerr



Abstract

ABCG2 is one of at least three human ATP binding cassette (ABC) transporters which can facilitate the export from cells of a wide range of chemically unrelated drug molecules. This capacity for multidrug transport is not only a confounding factor in chemotherapy, but is also one of the more perplexing phenomena in transporter biochemistry. Since its discovery in the last decade of the 20th century much has been revealed about ABCG2's localization, physiological function and its broad substrate range. There have also been many investigations of its structure and molecular mechanism. In this mini review article we take a Rumsfeldian approach to ABCG2 and essentially ask what we do know about this transporter, and what we will need to know about this transporter if we wish to use modulation of ABCG2 activity as a therapeutic approach.

Citation

Horsey, A. J., Cox, M. H., Sarwat, S., & Kerr, I. D. (2016). The multidrug transporter ABCG2: still more questions than answers. Biochemical Society Transactions, 44(3), https://doi.org/10.1042/BST20160014

Journal Article Type Article
Conference Name Biochemical Society: Membrane Proteins from Amino Acids to Zinc: A commemoration of the life and work of Prof. Stephen Baldwin
Acceptance Date Mar 21, 2016
Online Publication Date Jun 9, 2016
Publication Date Jun 15, 2016
Deposit Date Jun 21, 2016
Publicly Available Date Jun 21, 2016
Journal Biochemical Society Transactions
Print ISSN 0300-5127
Electronic ISSN 0300-5127
Publisher Portland Press
Peer Reviewed Peer Reviewed
Volume 44
Issue 3
DOI https://doi.org/10.1042/BST20160014
Public URL http://eprints.nottingham.ac.uk/id/eprint/34238
Publisher URL http://www.biochemsoctrans.org/content/44/3/824
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
Additional Information The final version of record is available at http://www.biochemsoctrans.org/content/44/3/824

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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