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An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy

Brownbill, Paul; Chernyavsky, Igor; Bottalico, Barbara; Desoye, Gernot; Hansson, Stefan; Kenna, Gerry; Knudsen, Lisbeth E.; Markert, Udo R.; Powles-Glover, Nicola; Schneider, Henning; Leach, Lopa

Authors

Paul Brownbill

Igor Chernyavsky

Barbara Bottalico

Gernot Desoye

Stefan Hansson

Gerry Kenna

Lisbeth E. Knudsen

Udo R. Markert

Nicola Powles-Glover

Henning Schneider

LOPA LEACH LOPA.LEACH@NOTTINGHAM.AC.UK
Associate Professor



Abstract

tThe human placenta is a critical life-support system that nourishes and protects a rapidly growing fetus; aunique organ, species specific in structure and function. We consider the pressing challenge of providingadditional advice on the safety of prescription medicines and environmental exposures in pregnancy andhow ex vivo and in vitro human placental models might be advanced to reproducible human placentaltest systems (HPTSs), refining a weight of evidence to the guidance given around compound risk assess-ment during pregnancy. The placental pharmacokinetics of xenobiotic transfer, dysregulated placentalfunction in pregnancy-related pathologies and influx/efflux transporter polymorphisms are a few caveatsthat could be addressed by HPTSs, not the specific focus of current mammalian reproductive toxicologysystems. An international consortium, “PlaNet”, will bridge academia, industry and regulators to con-sider screen ability and standardisation issues surrounding these models, with proven reproducibilityfor introduction into industrial and clinical practice.

Journal Article Type Article
Journal Reproductive Toxicology
Print ISSN 0890-6238
Electronic ISSN 0890-6238
Publisher Elsevier
Peer Reviewed Peer Reviewed
APA6 Citation Brownbill, P., Chernyavsky, I., Bottalico, B., Desoye, G., Hansson, S., Kenna, G., …Leach, L. (in press). An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy. Reproductive Toxicology, https://doi.org/10.1016/j.reprotox.2016.06.006
DOI https://doi.org/10.1016/j.reprotox.2016.06.006
Keywords PlaNet; Human placenta; Reproductive toxicology testing; 3Rs
Publisher URL http://dx.doi.org/10.1016/j.reprotox.2016.06.006
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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