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Early epigenetic reprogramming in fertilized, cloned, and parthenogenetic embryos

Sepulveda-Rincon, Lessly P.; Solanas, Edgar del Llano; Serrano-Revuelta, Elisa; Ruddick, Lydia; Maalouf, Walid E.; Beaujean, Nathalie

Early epigenetic reprogramming in fertilized, cloned, and parthenogenetic embryos Thumbnail


Lessly P. Sepulveda-Rincon

Edgar del Llano Solanas

Elisa Serrano-Revuelta

Lydia Ruddick

Walid E. Maalouf

Nathalie Beaujean


Despite ongoing research in a number of species, the efficiency of embryo production by nuclear transfer remains low. Incomplete epigenetic reprogramming of the nucleus introduced in the recipient oocyte is one factor proposed to limit the success of this technique. Nonetheless, knowledge of reprogramming factors has increased—thanks to comparative studies on reprogramming of the paternal genome brought by sperm on fertilization—and will be reviewed here. Another valuable model of reprogramming is the one obtained in the absence of sperm fertilization through artificial activation—the parthenote—and will also be introduced. Altogether the objective of this review is to have a better understanding on the mechanisms responsible for the resistance to reprogramming, not only because it could improve embryonic development but also as it could benefit therapeutic reprogramming research.


Sepulveda-Rincon, L. P., Solanas, E. D. L., Serrano-Revuelta, E., Ruddick, L., Maalouf, W. E., & Beaujean, N. (2016). Early epigenetic reprogramming in fertilized, cloned, and parthenogenetic embryos. Theriogenology, 86(1), 91-98.

Journal Article Type Article
Acceptance Date Mar 14, 2016
Online Publication Date Apr 21, 2016
Publication Date Jul 1, 2016
Deposit Date Feb 7, 2017
Publicly Available Date Feb 7, 2017
Journal Theriogenology
Print ISSN 0093-691X
Electronic ISSN 1879-3231
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 86
Issue 1
Pages 91-98
Keywords Oocyte; Nuclear transfer; Embryonic genome activation; Histones posttranslational modifications; DNA methylation
Public URL
Publisher URL


Sepulveda-Rincon_et_al-2016-Theriogenology submitted.pdf (353 Kb)

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