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Early epigenetic reprogramming in fertilized, cloned, and parthenogenetic embryos

Sepulveda-Rincon, Lessly P.; Solanas, Edgar del Llano; Serrano-Revuelta, Elisa; Ruddick, Lydia; Maalouf, Walid E.; Beaujean, Nathalie

Authors

Lessly P. Sepulveda-Rincon

Edgar del Llano Solanas

Elisa Serrano-Revuelta

Lydia Ruddick

Walid E. Maalouf

Nathalie Beaujean



Abstract

Despite ongoing research in a number of species, the efficiency of embryo production by nuclear transfer remains low. Incomplete epigenetic reprogramming of the nucleus introduced in the recipient oocyte is one factor proposed to limit the success of this technique. Nonetheless, knowledge of reprogramming factors has increased—thanks to comparative studies on reprogramming of the paternal genome brought by sperm on fertilization—and will be reviewed here. Another valuable model of reprogramming is the one obtained in the absence of sperm fertilization through artificial activation—the parthenote—and will also be introduced. Altogether the objective of this review is to have a better understanding on the mechanisms responsible for the resistance to reprogramming, not only because it could improve embryonic development but also as it could benefit therapeutic reprogramming research.

Citation

Sepulveda-Rincon, L. P., Solanas, E. D. L., Serrano-Revuelta, E., Ruddick, L., Maalouf, W. E., & Beaujean, N. (2016). Early epigenetic reprogramming in fertilized, cloned, and parthenogenetic embryos. Theriogenology, 86(1), 91-98. https://doi.org/10.1016/j.theriogenology.2016.04.022

Journal Article Type Article
Acceptance Date Mar 14, 2016
Online Publication Date Apr 21, 2016
Publication Date Jul 1, 2016
Deposit Date Feb 7, 2017
Publicly Available Date Feb 7, 2017
Journal Theriogenology
Print ISSN 0093-691X
Electronic ISSN 1879-3231
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 86
Issue 1
Pages 91-98
DOI https://doi.org/10.1016/j.theriogenology.2016.04.022
Keywords Oocyte; Nuclear transfer; Embryonic genome activation; Histones posttranslational modifications; DNA methylation
Public URL http://eprints.nottingham.ac.uk/id/eprint/40374
Publisher URL http://dx.doi.org/10.1016/j.theriogenology.2016.04.022
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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