Bernard Pereira
The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes
Pereira, Bernard; Chin, Suet-Feung; Rueda, Oscar M.; Vollan, Hans-Kristian Moen; Provenzano, Elena; Bardwell, Helen A.; Pugh, Michelle; Jones, Linda; Russell, Roslin; Sammut, Stephen-John; Tsui, Dana W.Y.; Liu, Bin; Dawson, Sarah-Jane; Abraham, Jean; Northen, Helen; Peden, John F.; Mukherjee, Abhik; Turashvili, Gulisa; Green, Andrew R.; McKinney, Steve; Oloumi, Arusha; Shah, Sohrab; Rosenfeld, Nitzan; Murphy, Leigh; Bentley, David R.; Ellis, Ian O.; Purushotham, Arnie; Pinder, Sarah E.; B�rresen-Dale, Anne-Lise; Earl, Helena M.; Pharoah, Paul D.; Ross, Mark T.; Aparicio, Samuel; Caldas, Carlos
Authors
Suet-Feung Chin
Oscar M. Rueda
Hans-Kristian Moen Vollan
Elena Provenzano
Helen A. Bardwell
Michelle Pugh
Linda Jones
Roslin Russell
Stephen-John Sammut
Dana W.Y. Tsui
Bin Liu
Sarah-Jane Dawson
Jean Abraham
Helen Northen
John F. Peden
Dr ABHIK MUKHERJEE ABHIK.MUKHERJEE1@NOTTINGHAM.AC.UK
Clinical Associate Professor
Gulisa Turashvili
Andrew R. Green
Steve McKinney
Arusha Oloumi
Sohrab Shah
Nitzan Rosenfeld
Leigh Murphy
David R. Bentley
Ian O. Ellis
Arnie Purushotham
Sarah E. Pinder
Anne-Lise B�rresen-Dale
Helena M. Earl
Paul D. Pharoah
Mark T. Ross
Samuel Aparicio
Carlos Caldas
Abstract
The genomic landscape of breast cancer is complex, and inter- and intra-tumour heterogeneity are important challenges in treating the disease. In this study, we sequence 173 genes in 2,433 primary breast tumours that have copy number aberration (CNA), gene expression and long-term clinical follow-up data. We identify 40 mutation-driver (Mut-driver) genes, and determine associations between mutations, driver CNA profiles, clinical-pathological parameters and survival. We assess the clonal states of Mut-driver mutations, and estimate levels of intra-tumour heterogeneity using mutant-allele fractions. Associations between PIK3CA mutations and reduced survival are identified in three subgroups of ER-positive cancer (defined by amplification of 17q23, 11q13–14 or 8q24). High levels of intra-tumour heterogeneity are in general associated with a worse outcome, but highly aggressive tumours with 11q13–14 amplification have low levels of intra-tumour heterogeneity. These results emphasize the importance of genome-based stratification of breast cancer, and have important implications for designing therapeutic strategies.
Citation
Pereira, B., Chin, S.-F., Rueda, O. M., Vollan, H.-K. M., Provenzano, E., Bardwell, H. A., …Caldas, C. (in press). The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes. Nature Communications, 7, Article 11479. https://doi.org/10.1038/ncomms11479
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 31, 2016 |
Online Publication Date | May 10, 2016 |
Deposit Date | Oct 18, 2016 |
Publicly Available Date | Oct 18, 2016 |
Journal | Nature Communications |
Electronic ISSN | 2041-1723 |
Publisher | Nature Publishing Group |
Peer Reviewed | Peer Reviewed |
Volume | 7 |
Article Number | 11479 |
DOI | https://doi.org/10.1038/ncomms11479 |
Public URL | https://nottingham-repository.worktribe.com/output/790562 |
Publisher URL | http://www.nature.com/articles/ncomms11479 |
Contract Date | Oct 18, 2016 |
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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