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The influence of nanotexturing of poly(lactic-co-glycolic acid) films upon human ovarian cancer cell attachment

Yaşayan, Gökçen; Xue, Xuan; Collier, Pamela; Clarke, Philip; Alexander, Morgan R.; Marlow, Maria

Authors

Gökçen Yaşayan

Xuan Xue

Pamela Collier

Philip Clarke

Morgan R. Alexander



Abstract

In this study, we have produced nanotextured poly(lactic-co-glycolic acid) (PLGA) films by using polystyrene (PS) particles as a template to make a polydimethylsiloxane mould against which PLGA is solvent cast. Biocompatible, biodegradable and nanotextured PLGA films were prepared with PS particles of diameter of 57, 99, 210, and 280 nm that produced domes of the same dimension in the PLGA surface. The effect of the particulate monolayer templating method was investigated to enable preparation of the films with uniformly ordered surface nanodomes. Cell attachment of a human ovarian cancer cell line (OVCAR3) alone and co-cultured with mesenchymal stem cells (MSCs) was evaluated on flat and topographically nano-patterned surfaces. Cell numbers were observed to increase on the nanotextured surfaces compared to non-textured surfaces both with OVCAR3 cultures and OVCAR3-MSC co-cultures at 24 and 48 h time points.

Citation

Yaşayan, G., Xue, X., Collier, P., Clarke, P., Alexander, M. R., & Marlow, M. (2016). The influence of nanotexturing of poly(lactic-co-glycolic acid) films upon human ovarian cancer cell attachment. Nanotechnology, 27(25), https://doi.org/10.1088/0957-4484/27/25/255102

Journal Article Type Article
Acceptance Date Apr 28, 2016
Publication Date May 17, 2016
Deposit Date Oct 3, 2016
Publicly Available Date Oct 3, 2016
Journal Nanotechnology
Print ISSN 0957-4484
Electronic ISSN 1361-6528
Publisher IOP Publishing
Peer Reviewed Peer Reviewed
Volume 27
Issue 25
DOI https://doi.org/10.1088/0957-4484/27/25/255102
Keywords nanotexturing, films, poly(lactic-co-glycolic acid), human ovarian cancer cell
Public URL http://eprints.nottingham.ac.uk/id/eprint/37328
Publisher URL http://iopscience.iop.org/article/10.1088/0957-4484/27/25/255102/meta
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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