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Anti-Food allergic activity of sulfated polysaccharide from Gracilaria lemaneiformisis dependent in immunosuppression and inhibition of p38 MAPK

Liu, Qing-Mei; Yang, Yang; Maleki, Soheila J.; Alcocer, Marcos; Xu, Sha-Sha; Shi, Chao-Lan; Cao, Min-Jie; Liu, Guang-Ming

Authors

Qing-Mei Liu

Yang Yang

Soheila J. Maleki

Marcos Alcocer

Sha-Sha Xu

Chao-Lan Shi

Min-Jie Cao

Guang-Ming Liu



Abstract

Polysaccharides from Gracilaria lemaneiformis in particular possess various bioactive functions, but their antiallergic activity remains incompletely defined. Sulfated polysaccharide from Gracilaria lemaneiformis (GLSP) was obtained by water extraction and ethanol precipitation followed by column chromatography. BALB/c mice, RBL-2H3, and KU812 cells were used for verifying the anti food allergic activity of GLSP. According to the results of mice experiment, GLSP was able to alleviate allergy symptoms, to reduce TM-specific IgE and IgG1, to suppress Th2 cell polarization, and to promote the function of regulatory T (Treg) cells. In addition, GLSP had the ability to inhibit the function of RBL-2H3 cells. Furthermore, GLSP inhibited the activation of KU812 via suppression of p38 mitogen-activated protein kinase (MAPK). In conclusion, immunosuppression as well as the reduction in the level of p38 MAPK may contribute to GLSP’s putative activity against food allergy. GLSP may be used as a functional food component for allergic patients.

Citation

Liu, Q., Yang, Y., Maleki, S. J., Alcocer, M., Xu, S., Shi, C., …Liu, G. (in press). Anti-Food allergic activity of sulfated polysaccharide from Gracilaria lemaneiformisis dependent in immunosuppression and inhibition of p38 MAPK. Journal of Agricultural and Food Chemistry, 64(22), https://doi.org/10.1021/acs.jafc.6b01086

Journal Article Type Article
Acceptance Date May 15, 2016
Online Publication Date May 17, 2016
Deposit Date Jul 3, 2017
Publicly Available Date Jul 3, 2017
Journal Journal of Agricultural and Food Chemistry
Print ISSN 0021-8561
Electronic ISSN 0021-8561
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 64
Issue 22
DOI https://doi.org/10.1021/acs.jafc.6b01086
Keywords food allergy; immunosuppression; p38 MAPK; sulfated polysaccharide from Gracilaria lemaneiformis
Public URL http://eprints.nottingham.ac.uk/id/eprint/43933
Publisher URL http://pubs.acs.org/doi/abs/10.1021/acs.jafc.6b01086
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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