Creatine ingestion augments dietary carbohydrate mediated muscle glycogen supercompensation during the initial 24h of recovery following prolonged exhaustive exercise in humans

Roberts, Paul A.; Fox, John; Peirce, Nicholas; Jones, Simon W.; Casey, Anna; Greenhaff, Paul L.

Abstract

Muscle glycogen availability can limit endurance exercise performance. We previously demonstrated 5 days of creatine (Cr) and carbohydrate (CHO) ingestion augmented post-exercise muscle glycogen storage compared to CHO feeding alone in healthy volunteers. Here we aimed to characterise the time-course of this Cr-induced response under more stringent and controlled experimental conditions and identify potential mechanisms underpinning this phenomenon. Fourteen healthy, male volunteers cycled to exhaustion at 70% VO2peak. Muscle biopsies were obtained at rest immediately post-exercise and after 1, 3 and 6 days of recovery, during which Cr or placebo supplements (20g.day-1) were ingested along with a prescribed high CHO diet (37.5 kcal.kg body mass-1.day-1, >80% calories CHO). Oral-glucose tolerance tests (oral-GTT) were performed pre-exercise and after 1, 3 and 6 days of Cr and placebo supplementation. Exercise depleted muscle glycogen content to the same extent in both treatment groups. Creatine supplementation increased muscle total-Cr, free-Cr and phosphocreatine (PCr) content above placebo following 1, 3 and 6 days of supplementation (all P

Citation

Roberts, P. A., Fox, J., Peirce, N., Jones, S. W., Casey, A., & Greenhaff, P. L. (2016). Creatine ingestion augments dietary carbohydrate mediated muscle glycogen supercompensation during the initial 24h of recovery following prolonged exhaustive exercise in humans. Amino Acids, 48(8), 1831–1842. https://doi.org/10.1007/s00726-016-2252-x

• Journal Article Type: Article
• Acceptance Date: May 3, 2016
• Online Publication Date: May 19, 2016
• Publication Date: 2016-08
• Deposit Date: May 20, 2016
• Publicly Available Date: May 20, 2016
• Journal: Amino Acids
• Print ISSN: 0939-4451
• Electronic ISSN: 1438-2199
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 48
• Issue: 8
• Pages: 1831–1842
• DOI: https://doi.org/10.1007/s00726-016-2252-x
• Keywords: Glycogen storage; Glucose tolerance; Phosphocreatine; Insulin sensitivity
• Public URL: https://nottingham-repository.worktribe.com/output/789612
• Publisher URL: http://link.springer.com/article/10.1007%2Fs00726-016-2252-x