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Ten-year outcomes in first episode psychotic major depression patients compared with schizophrenia and bipolar patients

Heslin, M.; Lappin, J.M.; Donoghue, K.; Lomas, B.; Reininghaus, U.; Onyejiaka, A.; Croudace, T.; Jones, P.B.; Murray, R.M.; Fearon, P.; Doody, G.A.; Dazzan, P.; Craig, T.J.; Morgan, C.

Authors

M. Heslin

J.M. Lappin

K. Donoghue

B. Lomas

U. Reininghaus

A. Onyejiaka

T. Croudace

P.B. Jones

R.M. Murray

P. Fearon

P. Dazzan

T.J. Craig

C. Morgan



Abstract

We aimed to investigate long-term outcomes in psychotic major depression patients compared to schizophrenia and bipolar/manic psychosis patients, in an incidence sample, while accounting for diagnostic change. Based on Aetiology and Ethnicity in Schizophrenia and Other Psychoses (/ESOP and /ESOP-10), a first episode psychosis cohort was followed-up 10 years after first presentation. The Schedules for Clinical Assessment in Neuropsychiatry, WHO Life Chart and Global Assessment of Functioning were used to assess clinical, social and service use outcomes. Seventy-two PMD patients, 218 schizophrenia patients and 70 psychotic bipolar disorder / mania patients were identified at baseline. Differences in outcome between PMD and bipolar patients based on baseline and lifetime diagnosis were minimal. Differences in clinical, social and service use outcomes between PMD and schizophrenia were more substantial with PMD patients showing better outcomes on most variables. However, there was some weak evidence (albeit not quite statistically significant at p < 0.05) based on lifetime diagnoses that PMD patients were more likely to attempt suicide (OR 2.31, CI 0.98-5.42, p0.055) and self-harm (OR 2.34, CI 0.97-5.68, p0.060). PMD patients have better social and service use outcomes compared to people with schizophrenia, but may be more likely to attempt suicide or self-harm. This unique profile is important for clinicians to consider in any risk assessment.

Citation

Heslin, M., Lappin, J., Donoghue, K., Lomas, B., Reininghaus, U., Onyejiaka, A., …Morgan, C. (2016). Ten-year outcomes in first episode psychotic major depression patients compared with schizophrenia and bipolar patients. Schizophrenia Research, 176(2-3), 417-422. https://doi.org/10.1016/j.schres.2016.04.049

Journal Article Type Article
Acceptance Date May 4, 2016
Online Publication Date May 26, 2016
Publication Date 2016-10
Deposit Date May 23, 2016
Publicly Available Date May 26, 2016
Journal Schizophrenia Research
Print ISSN 0920-9964
Electronic ISSN 1573-2509
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 176
Issue 2-3
Pages 417-422
DOI https://doi.org/10.1016/j.schres.2016.04.049
Keywords Psychotic major depression; Depression; Psychosis; Outcomes; Prognosis
Public URL http://eprints.nottingham.ac.uk/id/eprint/33097
Publisher URL http://www.sciencedirect.com/science/article/pii/S0920996416301980
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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Publisher Licence URL
http://creativecommons.org/licenses/by-nc-nd/3.0/

Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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