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Surface-enhanced Raman spectroscopy study of 4-ATP on gold nanoparticles for basal cell carcinoma fingerprint detection

Quynh, Luu Manh; Nam, Nguyen Hoang; Kong, K.; Nhung, Nguyen Thi; Notingher, Ioan; Henini, M.; Luong, Nguyen Hoang

Authors

Luu Manh Quynh

Nguyen Hoang Nam

K. Kong

Nguyen Thi Nhung

Ioan Notingher ioan.notingher@nottingham.ac.uk

M. Henini mohamed.henini@nottingham.ac.uk

Nguyen Hoang Luong



Abstract

The surface-enhanced Raman signals of 4-aminothiophenol (4-ATP) attached to the surface of colloidal gold nanoparticles with size distribution of 2 to 5 nm were used as a labeling agent to detect basal cell carcinoma (BCC) of the skin. The enhanced Raman band at 1075 cm-1 corresponding to the C-S stretching vibration in 4-ATP was observed during attachment to the surface of the gold nanoparticles. The frequency and intensity of this band did not change when the colloids were conjugated with BerEP4 antibody, which specifically binds to BCC. We show the feasibility of imaging BCC by surface-enhanced Raman spectroscopy, scanning the 1075 cm-1 band to detect the distribution of 4ATP-coated gold nanoparticles attached to skin tissue ex vivo.

Journal Article Type Article
Publication Date May 31, 2016
Journal Journal of Electronic Materials
Print ISSN 0361-5235
Electronic ISSN 1543-186X
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 45
Issue 5
APA6 Citation Quynh, L. M., Nam, N. H., Kong, K., Nhung, N. T., Notingher, I., Henini, M., & Luong, N. H. (2016). Surface-enhanced Raman spectroscopy study of 4-ATP on gold nanoparticles for basal cell carcinoma fingerprint detection. Journal of Electronic Materials, 45(5), https://doi.org/10.1007/s11664-016-4421-9
DOI https://doi.org/10.1007/s11664-016-4421-9
Keywords Skin cancer, Basal cell carcinoma, Surface-enhanced Raman scattering, Gold nanoparticles
Publisher URL http://link.springer.com/article/10.1007/s11664-016-4421-9
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information (c) 2016 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works.

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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