Judith A. C. Rietjens
Advance care planning, a multi-centre cluster randomised clinical trial: the research protocol of the ACTION study
Rietjens, Judith A. C.; Korfage, Ida J.; Dunleavy, Lesley; Preston, Nancy J.; Jabbarian, Lea J.; Christensen, Caroline Arnfeldt; de Brito, Maja; Bulli, Francesco; Caswell, Glenys; ?erv, Branka; van Delden, Johannes; Deliens, Luc; Gorini, Giuseppe; Groenvold, Mogens; Houttekier, Dirk; Ingravallo, Francesca; Kars, Marijke C.; Lunder, Ur�ka; Miccinesi, Guido; Mimi?, Alenka; Paci, Eugenio; Payne, Sheila; Polinder, Suzanne; Pollock, Kristian; Seymour, Jane; Simoni?, Anja; Johnsen, Anna Thit; Verkissen, Mari�tte N.; de Vries, Esther; Wilcock, Andrew; Zwakman, Marieke; van der Heide, Agnes
Authors
Ida J. Korfage
Lesley Dunleavy
Nancy J. Preston
Lea J. Jabbarian
Caroline Arnfeldt Christensen
Maja de Brito
Francesco Bulli
Glenys Caswell
Branka ?erv
Johannes van Delden
Luc Deliens
Giuseppe Gorini
Mogens Groenvold
Dirk Houttekier
Francesca Ingravallo
Marijke C. Kars
Ur�ka Lunder
Guido Miccinesi
Alenka Mimi?
Eugenio Paci
Sheila Payne
Suzanne Polinder
Kristian Pollock
Jane Seymour
Anja Simoni?
Anna Thit Johnsen
Mari�tte N. Verkissen
Esther de Vries
Andrew Wilcock
Marieke Zwakman
Agnes van der Heide
Abstract
Background: Awareness of preferences regarding medical care should be a central component of the care of patients with advanced cancer. Open communication can facilitate this but can occur in an ad hoc or variable manner. Advance care planning (ACP) is a formalized process of communication between patients, relatives and professional caregivers about patients’ values and care preferences. It raises awareness of the need to anticipate possible future deterioration of health. ACP has the potential to improve current and future healthcare decision making, provide patients with a sense of control, and improve their quality of life.
Methods/Design: We will study the effects of the ACP program Respecting Choices on the quality of life of patients with advanced lung or colorectal cancer. In a phase III multicenter cluster randomised controlled trial, 22 hospitals in 6 countries will be randomised. In the intervention sites, patients will be offered interviews with a trained facilitator. In the control sites, patients will receive care as usual. In total, 1360 patients will be included. All participating patients will be asked to complete questionnaires at inclusion, and again after 2.5 and 4.5 months. If a patient dies within a year after inclusion, a relative will be asked to complete a questionnaire on end-of-life care. Use of medical care will be assessed by checking medical files. The primary endpoint is patients’ quality of life at 2.5 months ost-inclusion. Secondary endpoints are the extent to which care as received is aligned with patients’ preferences, patients’ evaluation of decision-making processes, quality of end-of-life care and cost-effectiveness of the intervention. A complementary qualitative study will be carried out to explore the lived experience of engagement with the Respecting Choices program from the perspectives of patients, their Personal Representatives, healthcare providers and facilitators.
Discussion: Transferring the concept of ACP from care of the elderly to patients with advanced cancer, who on average are younger and retain their mental capacity for a larger part of their disease trajectory, is an important next step in an era of increased focus on patient centered healthcare and shared decision-making. Trial registration: International Standard Randomised Controlled Trial Number: ISRCTN63110516. Date of registration: 10/3/2014.
Keywords: Advance care planning, Oncology, Quality of life, Medical decision-making
Citation
Rietjens, J. A. C., Korfage, I. J., Dunleavy, L., Preston, N. J., Jabbarian, L. J., Christensen, C. A., de Brito, M., Bulli, F., Caswell, G., Červ, B., van Delden, J., Deliens, L., Gorini, G., Groenvold, M., Houttekier, D., Ingravallo, F., Kars, M. C., Lunder, U., Miccinesi, G., Mimić, A., …van der Heide, A. (2016). Advance care planning, a multi-centre cluster randomised clinical trial: the research protocol of the ACTION study. BMC Cancer, 16(264), https://doi.org/10.1186/s12885-016-2298-x
Journal Article Type | Article |
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Acceptance Date | Mar 30, 2016 |
Publication Date | Apr 8, 2016 |
Deposit Date | Jun 22, 2016 |
Publicly Available Date | Jun 22, 2016 |
Journal | BMC Cancer |
Electronic ISSN | 1471-2407 |
Publisher | Springer Verlag |
Peer Reviewed | Peer Reviewed |
Volume | 16 |
Issue | 264 |
DOI | https://doi.org/10.1186/s12885-016-2298-x |
Keywords | Advance care planning, Oncology, Quality of life, Medical decision-making |
Public URL | https://nottingham-repository.worktribe.com/output/785929 |
Publisher URL | http://bmccancer.biomedcentral.com/articles/10.1186/s12885-016-2298-x |
Contract Date | Jun 22, 2016 |
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0