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Ventral striatum connectivity during reward anticipation in adolescent smokers

Jollans, Lee; Zhipeng, Cao; Icke, Ilknur; Greene, Ciara; Kelly, Clare; Banaschewski, Tobias; Bokde, Arun L. W.; Bromberg, Uli; Büchel, Christian; Cattrell, Anna; Conrod, Patricia J.; Desrivières, Sylvane; Flor, Herta; Frouin, Vincent; Gallinat, Jürgen; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Artiges, Eric; Nees, Frauke; Papadopoulos Orfanos, Dimitri; Paus, Tomáš; Smolka, Michael N.; Walter, Henrik; Schumann, Gunter; Whelan, Robert

Authors

Lee Jollans

Cao Zhipeng

Ilknur Icke

Ciara Greene

Clare Kelly

Tobias Banaschewski

Arun L. W. Bokde

Uli Bromberg

Christian Büchel

Anna Cattrell

Patricia J. Conrod

Sylvane Desrivières

Herta Flor

Vincent Frouin

Jürgen Gallinat

Hugh Garavan

Andreas Heinz

Bernd Ittermann

Jean-Luc Martinot

Eric Artiges

Frauke Nees

Dimitri Papadopoulos Orfanos

Tomáš Paus

Michael N. Smolka

Henrik Walter

Gunter Schumann

Robert Whelan



Abstract

Substance misusers, including adolescent smokers, often have reduced reward system activity during processing of non-drug rewards. Using a psychophysiological interaction approach, we examined functional connectivity with the ventral striatum during reward anticipation in a large (N = 206) sample of adolescent smokers. Increased smoking frequency was associated with (1) increased connectivity with regions involved in saliency and valuation, including the orbitofrontal cortex and (2) reduced connectivity between the ventral striatum and regions associated with inhibition and risk aversion, including the right inferior frontal gyrus. These results demonstrate that functional connectivity during reward processing is relevant to adolescent addiction.

Journal Article Type Article
Journal Developmental Neuropsychology
Print ISSN 8756-5641
Electronic ISSN 1532-6942
Publisher Taylor & Francis (Routledge)
Peer Reviewed Peer Reviewed
Volume 41
Issue 1-2
APA6 Citation Jollans, L., Zhipeng, C., Icke, I., Greene, C., Kelly, C., Banaschewski, T., …Whelan, R. (in press). Ventral striatum connectivity during reward anticipation in adolescent smokers. Developmental Neuropsychology, 41(1-2), https://doi.org/10.1080/87565641.2016.1164172
DOI https://doi.org/10.1080/87565641.2016.1164172
Publisher URL http://www.tandfonline.com/doi/full/10.1080/87565641.2016.1164172
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information Date of acceptance is estimated. // This is an Accepted Manuscript of an article published by Taylor & Francis in Developmental Neuropsychology on 13 April 2016, available online: http://www.tandfonline..../87565641.2016.1164172.

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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