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Ventral striatum connectivity during reward anticipation in adolescent smokers

Authors

Lee Jollans

Cao Zhipeng

Ilknur Icke

Ciara Greene

Clare Kelly

Tobias Banaschewski

Arun L. W. Bokde

Uli Bromberg

Christian

Anna Cattrell

Patricia J. Conrod

Sylvane

Herta Flor

Vincent Frouin

Gallinat

Hugh Garavan

Andreas Heinz

Bernd Ittermann

Jean-Luc Martinot

Eric Artiges

Frauke Nees

Dimitri Papadopoulos Orfanos

Paus

Michael N. Smolka

Henrik Walter

Gunter Schumann

Robert Whelan



Abstract

Substance misusers, including adolescent smokers, often have reduced reward system activity during processing of non-drug rewards. Using a psychophysiological interaction approach, we examined functional connectivity with the ventral striatum during reward anticipation in a large (N = 206) sample of adolescent smokers. Increased smoking frequency was associated with (1) increased connectivity with regions involved in saliency and valuation, including the orbitofrontal cortex and (2) reduced connectivity between the ventral striatum and regions associated with inhibition and risk aversion, including the right inferior frontal gyrus. These results demonstrate that functional connectivity during reward processing is relevant to adolescent addiction.

Citation

Jollans, L., Zhipeng, C., Icke, I., Greene, C., Kelly, C., Banaschewski, T., …Whelan, R. (in press). Ventral striatum connectivity during reward anticipation in adolescent smokers. Developmental Neuropsychology, 41(1-2), https://doi.org/10.1080/87565641.2016.1164172

Journal Article Type Article
Acceptance Date Mar 15, 2016
Online Publication Date Apr 13, 2016
Deposit Date May 9, 2017
Publicly Available Date May 9, 2017
Journal Developmental Neuropsychology
Print ISSN 8756-5641
Electronic ISSN 1532-6942
Publisher Routledge
Peer Reviewed Peer Reviewed
Volume 41
Issue 1-2
DOI https://doi.org/10.1080/87565641.2016.1164172
Public URL https://nottingham-repository.worktribe.com/output/785375
Publisher URL http://www.tandfonline.com/doi/full/10.1080/87565641.2016.1164172
Additional Information Date of acceptance is estimated. // This is an Accepted Manuscript of an article published by Taylor & Francis in Developmental Neuropsychology on 13 April 2016, available online: http://www.tandfonline.com/10.1080/87565641.2016.1164172.

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