Ventral striatum connectivity during reward anticipation in adolescent smokers

Jollans, Lee; Zhipeng, Cao; Icke, Ilknur; Greene, Ciara; Kelly, Clare; Banaschewski, Tobias; Bokde, Arun L. W.; Bromberg, Uli; B�chel, Christian; Cattrell, Anna; Conrod, Patricia J.; Desrivi�res, Sylvane; Flor, Herta; Frouin, Vincent; Gallinat, J�rgen; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Artiges, Eric; Nees, Frauke; Papadopoulos Orfanos, Dimitri; Paus, Tom�; Smolka, Michael N.; Walter, Henrik; Schumann, Gunter; Whelan, Robert

Abstract

Substance misusers, including adolescent smokers, often have reduced reward system activity during processing of non-drug rewards. Using a psychophysiological interaction approach, we examined functional connectivity with the ventral striatum during reward anticipation in a large (N = 206) sample of adolescent smokers. Increased smoking frequency was associated with (1) increased connectivity with regions involved in saliency and valuation, including the orbitofrontal cortex and (2) reduced connectivity between the ventral striatum and regions associated with inhibition and risk aversion, including the right inferior frontal gyrus. These results demonstrate that functional connectivity during reward processing is relevant to adolescent addiction.

Citation

Jollans, L., Zhipeng, C., Icke, I., Greene, C., Kelly, C., Banaschewski, T., Bokde, A. L. W., Bromberg, U., Büchel, C., Cattrell, A., Conrod, P. J., Desrivières, S., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.-L., …Whelan, R. (in press). Ventral striatum connectivity during reward anticipation in adolescent smokers. Developmental Neuropsychology, 41(1-2), https://doi.org/10.1080/87565641.2016.1164172

• Journal Article Type: Article
• Acceptance Date: Mar 15, 2016
• Online Publication Date: Apr 13, 2016
• Deposit Date: May 9, 2017
• Publicly Available Date: May 9, 2017
• Journal: Developmental Neuropsychology
• Print ISSN: 8756-5641
• Electronic ISSN: 1532-6942
• Publisher: Routledge
• Peer Reviewed: Peer Reviewed
• Volume: 41
• Issue: 1-2
• DOI: https://doi.org/10.1080/87565641.2016.1164172
• Public URL: https://nottingham-repository.worktribe.com/output/785375
• Publisher URL: http://www.tandfonline.com/doi/full/10.1080/87565641.2016.1164172
• Additional Information: Date of acceptance is estimated. // This is an Accepted Manuscript of an article published by Taylor & Francis in Developmental Neuropsychology on 13 April 2016, available online: http://www.tandfonline.com/10.1080/87565641.2016.1164172.
• Contract Date: May 9, 2017