Skip to main content

Research Repository

Advanced Search

Ventral striatum connectivity during reward anticipation in adolescent smokers


Lee Jollans

Cao Zhipeng

Ilknur Icke

Ciara Greene

Clare Kelly

Tobias Banaschewski

Arun L. W. Bokde

Uli Bromberg


Anna Cattrell

Patricia J. Conrod


Herta Flor

Vincent Frouin


Hugh Garavan

Andreas Heinz

Bernd Ittermann

Jean-Luc Martinot

Eric Artiges

Frauke Nees

Dimitri Papadopoulos Orfanos


Michael N. Smolka

Henrik Walter

Gunter Schumann

Robert Whelan


Substance misusers, including adolescent smokers, often have reduced reward system activity during processing of non-drug rewards. Using a psychophysiological interaction approach, we examined functional connectivity with the ventral striatum during reward anticipation in a large (N = 206) sample of adolescent smokers. Increased smoking frequency was associated with (1) increased connectivity with regions involved in saliency and valuation, including the orbitofrontal cortex and (2) reduced connectivity between the ventral striatum and regions associated with inhibition and risk aversion, including the right inferior frontal gyrus. These results demonstrate that functional connectivity during reward processing is relevant to adolescent addiction.


Jollans, L., Zhipeng, C., Icke, I., Greene, C., Kelly, C., Banaschewski, T., …Whelan, R. (in press). Ventral striatum connectivity during reward anticipation in adolescent smokers. Developmental Neuropsychology, 41(1-2),

Journal Article Type Article
Acceptance Date Mar 15, 2016
Online Publication Date Apr 13, 2016
Deposit Date May 9, 2017
Publicly Available Date May 9, 2017
Journal Developmental Neuropsychology
Print ISSN 8756-5641
Electronic ISSN 1532-6942
Publisher Routledge
Peer Reviewed Peer Reviewed
Volume 41
Issue 1-2
Public URL
Publisher URL
Additional Information Date of acceptance is estimated. // This is an Accepted Manuscript of an article published by Taylor & Francis in Developmental Neuropsychology on 13 April 2016, available online:


You might also like

Downloadable Citations