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Synthesis of triazole-linked morpholino oligonucleotides via Cu1 catalysed cycloaddition

Palframan, Matthew J.; Alharthy, Rima D.; Powalowska, Paulina K.; Hayes, Christopher J.

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Authors

Matthew J. Palframan

Rima D. Alharthy

Paulina K. Powalowska

CHRIS HAYES chris.hayes@nottingham.ac.uk
Professor of Organic Chemistry



Abstract

Triazole-linked morpholino (TLMO) oligonucleic acids were synthesised using the CuI catalysed (3 + 2) azide–alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase synthesis. UV melting experiments showed that the TLMO modification gives higher Tm values than the corresponding TLDNA modification.

Citation

Palframan, M. J., Alharthy, R. D., Powalowska, P. K., & Hayes, C. J. (in press). Synthesis of triazole-linked morpholino oligonucleotides via Cu1 catalysed cycloaddition. Organic and Biomolecular Chemistry, 14, https://doi.org/10.1039/C6OB00007J

Journal Article Type Article
Acceptance Date Feb 16, 2016
Online Publication Date Feb 16, 2016
Deposit Date Jul 26, 2016
Publicly Available Date Jul 26, 2016
Journal Organic and Biomolecular Chemistry
Print ISSN 1477-0520
Electronic ISSN 1477-0520
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 14
DOI https://doi.org/10.1039/C6OB00007J
Public URL https://nottingham-repository.worktribe.com/output/776187
Publisher URL http://dx.doi.org/10.1039/C6OB00007J

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