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Oral vaccination with a rough attenuated mutant of S. Infantis increases post-wean weight gain and prevents clinical signs of salmonellosis in S. Typhimurium challenged pigs

Foster, Neil; Richards, Luke; Higgins, John; Kanellos, Theo; Barrow, Paul

Authors

Neil Foster

Luke Richards

John Higgins

Theo Kanellos

Paul Barrow



Abstract

We show that oral inoculation of 14 day old conventional piglets with a rough attenuated Salmonella enterica serovar Infantis 1326/28Фr (serogroup C1), 24 h prior to oral challenge with S. enterica serovar Typhimurium 4/74 (serogroup B), resulted in significant weight gain (~ 10%) measured at 14 days post-weaning (38 days of age). Two days after challenge the S. Typhimurium induced stunting and, in some cases loss, of villi but this was prevented by pre-inoculation with the S. Infantis strain. The clinical signs of disease associated with S. Typhimurium 4/74 challenge and faecal shedding were also significantly (P < 0.05) reduced by pre-inoculation with the S. Infantis mutant. Pre-inoculation of pigs with the S. Infantis mutant also increased weight gain in pigs challenged with pathogenic Escherichia coli. However, Mycobacterium bovis BCG, an unrelated intracellular bacterium, did not protect against challenge with S. Typhimurium 4/74.

Citation

Foster, N., Richards, L., Higgins, J., Kanellos, T., & Barrow, P. (2016). Oral vaccination with a rough attenuated mutant of S. Infantis increases post-wean weight gain and prevents clinical signs of salmonellosis in S. Typhimurium challenged pigs. Research in Veterinary Science, 104, https://doi.org/10.1016/j.rvsc.2015.12.013

Journal Article Type Article
Acceptance Date Dec 22, 2015
Online Publication Date Dec 23, 2015
Publication Date Feb 28, 2016
Deposit Date Mar 27, 2017
Publicly Available Date Mar 27, 2017
Journal Research in Veterinary Science
Print ISSN 0034-5288
Electronic ISSN 1532-2661
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 104
DOI https://doi.org/10.1016/j.rvsc.2015.12.013
Keywords Salmonella; Pigs; Serogroup; Vaccine; Innate immunity; Weight gain
Public URL http://eprints.nottingham.ac.uk/id/eprint/41586
Publisher URL https://doi.org/10.1016/j.rvsc.2015.12.013
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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