Impact of direct acting antiviral therapy in patients with chronic hepatitis C and decompensated cirrhosis

Foster, Graham R.; Irving, William L.; Cheung, Michelle C.M.; Walker, Alex J.; Hudson, Benjamin E.; Verma, Suman; McLauchlan, John; Mutimer, David J.; Brown, Ashley; Gelson, William T.H.; MacDonald, Douglas C.; Agarwal, Kosh

Abstract

© 2016 European Association for the Study of the Liver. Background & Aims All oral direct acting antivirals (DAAs) effectively treat chronic hepatitis C virus (HCV) infection, but the benefits in advanced liver disease are unclear. We compared outcomes in treated and untreated patients with decompensated cirrhosis. Methods Patients with HCV and decompensated cirrhosis or at risk of irreversible disease were treated in an expanded access programme (EAP) in 2014. Treatment, by clinician choice, was with sofosbuvir, ledipasvir or daclatasvir, with or without ribavirin. For functional outcome comparison, untreated patients with HCV and decompensated cirrhosis who were registered on a database 6 months before treatment was available were retrospectively studied. Primary endpoint was sustained virological response 12 weeks post antiviral treatment (treated cohort) and the secondary endpoint (both cohorts) was adverse outcomes (worsening in MELD score or serious adverse event) within 6 months. Results 467 patients received treatment (409 decompensated cirrhosis). Viral clearance was achieved in 381 patients (81.6%) - 209 from 231 (90.5%) with genotype 1 and 132 from 192 (68.8%) with genotype 3. MELD scores improved in treated patients (mean change -0.85) but worsened in untreated patients (mean + 0.75) (p

• Journal Article Type: Article
• Acceptance Date: Jan 25, 2016
• Online Publication Date: Jan 30, 2016
• Publication Date: Jun 1, 2016
• Deposit Date: Mar 18, 2016
• Publicly Available Date: Mar 18, 2016
• Journal: Journal of Hepatology
• Print ISSN: 0168-8278
• Electronic ISSN: 1600-0641
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 64
• Issue: 6
• Pages: 1224-1231
• DOI: https://doi.org/10.1016/j.jhep.2016.01.029
• Keywords: Hepatitis C virus; Sofosbuvir; Ledipasvir; Daclatasvir; MELD score; Decompensated cirrhosis
• Public URL: https://nottingham-repository.worktribe.com/output/771284
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S0168827816000659
• Additional Information: This article is maintained by: Elsevier; Article Title: Impact of direct acting antiviral therapy in patients with chronic hepatitis C and decompensated cirrhosis; Journal Title: Journal of Hepatology; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.jhep.2016.01.029; Content Type: article; Copyright: © 2016 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.