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Au(I) N-heterocyclic carbenes from bisimidazolium amphiphiles: synthesis, cytotoxicity and incorporation onto gold nanoparticles

Rodrigues, Mafalda; Russo, Lorenzo; Aguilo, E.; Rodriguez, L.; Ott, I.; P�rez-Garc�a, Llu�sa

Authors

Mafalda Rodrigues

Lorenzo Russo

E. Aguilo

L. Rodriguez

I. Ott

Llu�sa P�rez-Garc�a



Abstract

A gold(I) N-heterocyclic carbene 4 from a bis-imidazolium-amphiphile was synthesized and characterized. The cytotoxicity against HT-29 colon carcinoma and MDA-MB-231 breast adenocarcinoma cells was assessed for the NHC complex 4, the imidazolium salt precursor 2, and its methyl analogue 3, indicating that compounds 2–4 are promising cytotoxic agents. Furthermore, the ability of these compounds to be associated with gold nanoparticles was also explored, in order to develop an anticancer drug delivery system. The free ligands displayed more activity when compared with the ligands immobilized on the gold nanoparticles. The synthesized gold particles incorporating the bis-imidazolium salts either 2 or 3 showed monodisperse spherical shape with sizes of approximately 5 nm.

Citation

Rodrigues, M., Russo, L., Aguilo, E., Rodriguez, L., Ott, I., & Pérez-García, L. (2015). Au(I) N-heterocyclic carbenes from bisimidazolium amphiphiles: synthesis, cytotoxicity and incorporation onto gold nanoparticles. RSC Advances, 6, https://doi.org/10.1039/C5RA21621D

Journal Article Type Article
Acceptance Date Dec 17, 2015
Publication Date Dec 22, 2015
Deposit Date Jul 13, 2018
Publicly Available Date Mar 29, 2024
Journal RSC Advances (Deleted)
Print ISSN 2046-2069
Electronic ISSN 2046-2069
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 6
DOI https://doi.org/10.1039/C5RA21621D
Public URL https://nottingham-repository.worktribe.com/output/768843
Publisher URL http://pubs.rsc.org/en/Content/ArticleLanding/2016/RA/C5RA21621D#!divAbstract

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