Development and validation of risk prediction equations to estimate future risk of blindness and lower limb amputation in patients with diabetes: cohort study

Hippisley-Cox, Julia; Coupland, Carol

Abstract

Study question: Is it possible to develop and externally validate risk prediction equations to estimate the 10 year risk of blindness and lower limb amputation in patients with diabetes aged 25-84 years?

Methods: This was a prospective cohort study using routinely collected data from general practices in England contributing to the QResearch and Clinical Practice Research Datalink (CPRD) databases during the study period 1998-2014. The equations were developed using 763 QResearch practices (n=454 575 patients with diabetes) and validated in 254 different QResearch practices (n=142 419) and 357 CPRD practices (n=206 050). Cox proportional hazards models were used to derive separate risk equations for blindness and amputation in men and women that could be evaluated at 10 years. Measures of calibration and discrimination were calculated in the two validation cohorts.

Study answer and limitations: Risk prediction equations to quantify absolute risk of blindness and amputation in men and women with diabetes have been developed and externally validated. In the QResearch derivation cohort, 4822 new cases of lower limb amputation and 8063 new cases of blindness occurred during follow-up. The risk equations were well calibrated in both validation cohorts. Discrimination was good in men in the external CPRD cohort for amputation (D statistic 1.69, Harrell’s C statistic 0.77) and blindness (D statistic 1.40, Harrell’s C statistic 0.73), with similar results in women and in the QResearch validation cohort. The algorithms are based on variables that patients are likely to know or that are routinely recorded in general practice computer systems. They can be used to identify patients at high risk for prevention or further assessment. Limitations include lack of formally adjudicated outcomes, information bias, and missing data.

What this study adds: Patients with type 1 or type 2 diabetes are at increased risk of blindness and amputation but generally do not have accurate assessments of the magnitude of their individual risks. The new algorithms calculate the absolute risk of developing these complications over a 10 year period in patients with diabetes, taking account of their individual risk factors.

Citation

Hippisley-Cox, J., & Coupland, C. (2015). Development and validation of risk prediction equations to estimate future risk of blindness and lower limb amputation in patients with diabetes: cohort study. BMJ, 351, Article h5441. https://doi.org/10.1136/bmj.h5441

• Journal Article Type: Article
• Acceptance Date: Sep 29, 2015
• Publication Date: Nov 11, 2015
• Deposit Date: Oct 27, 2017
• Publicly Available Date: Oct 27, 2017
• Journal: BMJ
• Print ISSN: 0959-8138
• Electronic ISSN: 1756-1833
• Publisher: BMJ Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 351
• Article Number: h5441
• DOI: https://doi.org/10.1136/bmj.h5441
• Keywords: Development and validation; Risk prediction Equations; Blindness; Lower limb amputation; Diabetes; Primary care; Database research; QResearch; Clinical Practice Research Datalink
• Public URL: https://nottingham-repository.worktribe.com/output/767123
• Publisher URL: http://www.bmj.com/content/351/bmj.h5441
• Contract Date: Oct 27, 2017