Circular RNA in disease: Basic properties and biomedical relevance

Chen, Xiaolan; Zhou, Min; Yant, Levi; Huang, Chuan

Abstract

Circular RNAs (circRNAs) represent a class of covalently closed RNA molecules with great diversity in molecular features, functions, and regulatory mechanisms. Emerging advances in our understanding of circRNA biogenesis, nuclear export, and stability control have been made very recently. In particular, novel roles of circRNAs in diverse human diseases are increasingly recognized. Various circRNAs have been found to affect many disease-relevant pathways through a diverse array of mechanisms, including forming R-loops, sponging miRNAs or proteins, and translating functional proteins, resulting in different pathological phenotypes. This recent progress calls for a revised view of circRNAs in diseases threatening the lives and health of humans. In this review, we focus on the recently described functional relevance of disease-associated circRNAs as well as the potential of circRNAs in diverse clinical applications. This article is categorized under: RNA in Disease and Development > RNA in Disease Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs.

Citation

Chen, X., Zhou, M., Yant, L., & Huang, C. (2022). Circular RNA in disease: Basic properties and biomedical relevance. Wiley Interdisciplinary Reviews: RNA, 13(6), Article e1723. https://doi.org/10.1002/wrna.1723

• Journal Article Type: Review
• Acceptance Date: Dec 14, 2021
• Online Publication Date: Feb 22, 2022
• Publication Date: 2022-11
• Deposit Date: Nov 20, 2024
• Journal: Wiley Interdisciplinary Reviews: RNA
• Print ISSN: 1757-7004
• Electronic ISSN: 1757-7012
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 13
• Issue: 6
• Article Number: e1723
• DOI: https://doi.org/10.1002/wrna.1723
• Public URL: https://nottingham-repository.worktribe.com/output/7612002
• Publisher URL: https://wires.onlinelibrary.wiley.com/doi/10.1002/wrna.1723
• Additional Information: Received: 2021-09-29; Accepted: 2022-01-31; Published: 2022-02-22