Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy

Rawling, M.J.; Storr, T.E.; Bawazir, W.A.; Cully, S.J.; Lewis, W.; Makki, M.S.I.T.; Strutt, I.R.; Jones, G.; Hamza, D.; Stockman, R.A.

Abstract

A heterocyclic, sp3-rich chemical scaffold was synthesised in just 6 steps via a highly regio- and diastereo-selective tandem nitrone formation/intramolecular nitrone–alkene [3+2] cycloaddition reaction. A library of 543 lead-like compounds based on the scaffold core has been produced.

Citation

Rawling, M., Storr, T., Bawazir, W., Cully, S., Lewis, W., Makki, M., Strutt, I., Jones, G., Hamza, D., & Stockman, R. (2015). Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy. Chemical Communications, 51(64), https://doi.org/10.1039/c5cc05070g

• Journal Article Type: Article
• Acceptance Date: Jul 9, 2015
• Publication Date: Jul 9, 2015
• Deposit Date: Sep 28, 2017
• Publicly Available Date: Sep 28, 2017
• Journal: Chemical Communications
• Print ISSN: 1359-7345
• Electronic ISSN: 1364-548X
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 51
• Issue: 64
• DOI: https://doi.org/10.1039/c5cc05070g
• Public URL: https://nottingham-repository.worktribe.com/output/757348
• Publisher URL: http://pubs.rsc.org/en/Content/ArticleLanding/2015/CC/C5CC05070G#!divAbstract
• Contract Date: Sep 28, 2017