Phytotoxin production in Aspergillus terreus is regulated by independent environmental signals

Gressler, Markus; Meyer, Florian; Heine, Daniel; Hortschansky, Peter; Hertweck, Christian; Brock, Matthias

Abstract

Secondary metabolites have a great potential as pharmaceuticals, but there are only a few examples where regulation of gene cluster expression has been correlated with ecological and physiological relevance for the producer. Here, signals, mediators, and biological effects of terrein production were studied in the fungus Aspergillus terreus to elucidate the contribution of terrein to ecological competition. Terrein causes fruit surface lesions and inhibits plant seed germination. Additionally, terrein is moderately antifungal and reduces ferric iron, thereby supporting growth of A. terreus under iron starvation. In accordance, the lack of nitrogen or iron or elevated methionine levels induced terrein production and was dependent on either the nitrogen response regulators AreA and AtfA or the iron response regulator HapX. Independent signal transduction allows complex sensing of the environment and, combined with its broad spectrum of biological activities, terrein provides a prominent example of adapted secondary metabolite production in response to environmental competition.

Citation

Gressler, M., Meyer, F., Heine, D., Hortschansky, P., Hertweck, C., & Brock, M. (2015). Phytotoxin production in Aspergillus terreus is regulated by independent environmental signals. eLife, 4, Article e07861. https://doi.org/10.7554/eLife.07861.001

• Journal Article Type: Article
• Acceptance Date: Jul 13, 2015
• Publication Date: Jul 14, 2015
• Deposit Date: Mar 14, 2017
• Publicly Available Date: Mar 14, 2017
• Journal: eLife
• Electronic ISSN: 2050-084X
• Publisher: eLife Sciences Publications
• Peer Reviewed: Peer Reviewed
• Volume: 4
• Article Number: e07861
• DOI: https://doi.org/10.7554/eLife.07861.001
• Public URL: https://nottingham-repository.worktribe.com/output/757038
• Publisher URL: https://elifesciences.org/articles/07861
• Contract Date: Mar 14, 2017