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Association between psychological distress and liver disease mortality: a meta-analysis of individual study participants

Russ, Tom C.; Kivimäki, Mika; Morling, Joanne R.; Starr, John M.; Stamatakis, Emmanuel; Batty, G. David

Authors

Tom C. Russ

Mika Kivimäki

JOANNE MORLING JOANNE.MORLING@NOTTINGHAM.AC.UK
Clinician Scientist Fellowin Public Health

John M. Starr

Emmanuel Stamatakis

G. David Batty



Abstract

Background & Aims: Risk factors for cardiovascular disease, such as obesity and hypertension, have been associated with non-alcoholic fatty liver disease. Psychological distress (symptoms of anxiety and depression) is a risk factor for cardiovascular disease, so it might also be associated, directly or indirectly, with elevated rates of liver disease. We investigated the relation of psychological distress (measured by the 12-item General Health Questionnaire; GHQ) with liver disease mortality.

Methods: We performed a meta-analysis of data from individual participants in 16 prospective studies of the general population of the UK, initiated from 1994 through 2008. We categorized GHQ score into four groups: zero (no distress), 1-3, 4-6, and 7-12.

Results: We used data from 166,631 individuals (55% women; age, 46.6±18.4 years; range, 16−102 years). During a mean follow-up period of 9.5 years, 17,368 participants died (457 with liver disease). We found a significant increase in risk for liver disease mortality as GHQ score increased across categories (ptrend

Journal Article Type Article
Journal Gastroenterology
Print ISSN 2308-2097
Electronic ISSN 0016-5085
Publisher Publishing House Zaslavsky
Peer Reviewed Peer Reviewed
Volume 148
Issue 5
Article Number 958-966.e4
APA6 Citation Russ, T. C., Kivimäki, M., Morling, J. R., Starr, J. M., Stamatakis, E., & Batty, G. D. (in press). Association between psychological distress and liver disease mortality: a meta-analysis of individual study participants. Gastroenterology, 148(5), https://doi.org/10.1053/j.gastro.2015.02.004
DOI https://doi.org/10.1053/j.gastro.2015.02.004
Keywords Steatosis, Cirrhosis, Mental health, GHQ-12; Death
Publisher URL https://www.sciencedirect.com/science/article/pii/S001650851500195X?via%3Dihub
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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