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Linifanib – a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator

Marlow, Maria; Al-Ameedee, Mohammed; Smith, Thomas; Wheeler, Simon; Stocks, Michael J.

Authors

Mohammed Al-Ameedee

Thomas Smith

Simon Wheeler

MICHAEL STOCKS MICHAEL.STOCKS@NOTTINGHAM.AC.UK
Professor of Medicinal Chemistryand Drug Discovery



Abstract

In this study we demonstrate that linifanib, a multi-targeted receptor tyrosine kinase inhibitor, with a key urea containing pharmacophore, self-assembles into a hydrogel in the presence of low amounts of solvent. We demonstrate the role of the urea functional group and that of fluorine substitution on the adjacent aromatic ring in promoting self-assembly. We have also shown that linifanib has superior mechanical strength to two structurally related analogues and hence increased potential for localisation at an injection site for drug delivery applications.

Citation

Marlow, M., Al-Ameedee, M., Smith, T., Wheeler, S., & Stocks, M. J. (in press). Linifanib – a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator. Chemical Communications, 51, https://doi.org/10.1039/c5cc00454c

Journal Article Type Article
Acceptance Date Feb 26, 2015
Online Publication Date Feb 27, 2015
Deposit Date Nov 21, 2017
Publicly Available Date Nov 21, 2017
Journal Chemical Communications
Print ISSN 1359-7345
Electronic ISSN 1364-548X
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 51
DOI https://doi.org/10.1039/c5cc00454c
Public URL http://eprints.nottingham.ac.uk/id/eprint/48294
Publisher URL http://pubs.rsc.org/en/Content/ArticleLanding/2015/CC/C5CC00454C#!divAbstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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