MARIA MARLOW Maria.Marlow@nottingham.ac.uk
Associate Professor
Linifanib – a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator
Marlow, Maria; Al-Ameedee, Mohammed; Smith, Thomas; Wheeler, Simon; Stocks, Michael J.
Authors
Mohammed Al-Ameedee
Thomas Smith
Simon Wheeler
MICHAEL STOCKS MICHAEL.STOCKS@NOTTINGHAM.AC.UK
Professor of Medicinal Chemistry and Drug Discovery
Abstract
In this study we demonstrate that linifanib, a multi-targeted receptor tyrosine kinase inhibitor, with a key urea containing pharmacophore, self-assembles into a hydrogel in the presence of low amounts of solvent. We demonstrate the role of the urea functional group and that of fluorine substitution on the adjacent aromatic ring in promoting self-assembly. We have also shown that linifanib has superior mechanical strength to two structurally related analogues and hence increased potential for localisation at an injection site for drug delivery applications.
Citation
Marlow, M., Al-Ameedee, M., Smith, T., Wheeler, S., & Stocks, M. J. (in press). Linifanib – a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator. Chemical Communications, 51, https://doi.org/10.1039/c5cc00454c
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 26, 2015 |
Online Publication Date | Feb 27, 2015 |
Deposit Date | Nov 21, 2017 |
Publicly Available Date | Mar 28, 2024 |
Journal | Chemical Communications |
Print ISSN | 1359-7345 |
Electronic ISSN | 1364-548X |
Publisher | Royal Society of Chemistry |
Peer Reviewed | Peer Reviewed |
Volume | 51 |
DOI | https://doi.org/10.1039/c5cc00454c |
Public URL | https://nottingham-repository.worktribe.com/output/744321 |
Publisher URL | http://pubs.rsc.org/en/Content/ArticleLanding/2015/CC/C5CC00454C#!divAbstract |
Files
c5cc00454c.pdf
(2.4 Mb)
PDF
Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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