Igor B. Mekjavic
Energy Intake of Men With Excess Weight During Normobaric Hypoxic Confinement
Mekjavic, Igor B.; Amon, Mojca; Simpson, Elizabeth J.; Kölegård, Roger; Eiken, Ola; Macdonald, Ian A.
Authors
Mojca Amon
Elizabeth J. Simpson
Roger Kölegård
Ola Eiken
Ian A. Macdonald
Abstract
Due to the observations of weight loss at high altitude, normobaric hypoxia has been considered as a method of weight loss in obese individuals. With this regard, the aim of the present study was to determine the effect of hypoxia per se on metabolism in men with excess weight. Eight men living with excess weight (125.0 ± 17.7 kg; 30.5 ± 11.1 years, BMI: 37.6 ± 6.2 kg⋅m–2) participated in a randomized cross-over study comprising two 10-day confinements: normobaric (altitude of facility ≃ 940 m) normoxia (NORMOXIA; PIO2 = 133 mmHg), and normobaric hypoxia (HYPOXIA). The PIO2 in the latter was reduced from 105 (simulated altitude of 2,800 m) to 98 mmHg (simulated altitude of 3,400 m over 10 days. Before, and at the end of each confinement, participants completed a meal tolerance test (MTT). Resting energy expenditure (REE), circulating glucose, GLP-1, insulin, catecholamines, ghrelin, peptide-YY (PYY), leptin, gastro-intestinal blood flow, and appetite sensations were measured in fasted and postprandial states. Fasting REE increased after HYPOXIA (+358.0 ± 49.3 kcal⋅day–1, p = 0.03), but not after NORMOXIA (−33.1 ± 17.6 kcal⋅day–1). Postprandial REE was also significantly increased after HYPOXIA (p ≤ 0.05), as was the level of PYY. Furthermore, a tendency for decreased energy intake was concomitant with a significant body weight reduction after HYPOXIA (−0.7 ± 0.2 kg) compared to NORMOXIA (+1.0 ± 0.2 kg). The HYPOXIA trial increased the metabolic requirements, with a tendency toward decreased energy intake concomitant with increased PYY levels supporting the notion of a hypoxia-induced appetite inhibition, that could potentially lead to body weight reduction. The greater postprandial blood-glucose response following hypoxic confinement, suggests the potential development of insulin resistance.
Citation
Mekjavic, I. B., Amon, M., Simpson, E. J., Kölegård, R., Eiken, O., & Macdonald, I. A. (2022). Energy Intake of Men With Excess Weight During Normobaric Hypoxic Confinement. Frontiers in Physiology, 12, Article 801833. https://doi.org/10.3389/fphys.2021.801833
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 16, 2021 |
Online Publication Date | Jan 12, 2022 |
Publication Date | Jan 12, 2022 |
Deposit Date | Nov 25, 2022 |
Publicly Available Date | Nov 30, 2022 |
Journal | Frontiers in Physiology |
Electronic ISSN | 1664-042X |
Publisher | Frontiers Media |
Peer Reviewed | Peer Reviewed |
Volume | 12 |
Article Number | 801833 |
DOI | https://doi.org/10.3389/fphys.2021.801833 |
Keywords | Physiology (medical); Physiology |
Public URL | https://nottingham-repository.worktribe.com/output/7378787 |
Publisher URL | https://www.frontiersin.org/articles/10.3389/fphys.2021.801833/full |
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Energy Intake of Men With Excess Weight During Normobaric Hypoxic Confinement
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