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Cannabinoid-mediated short-term plasticity in hippocampus

Zachariou, Margarita; Thul, Ruediger


Margarita Zachariou


Endocannabinoids modulate both excitatory and inhibitory neurotransmission in hippocampus via activation of pre-synaptic cannabinoid receptors. Here, we present a model for cannabinoid mediated short-term depression of excitation (DSE) based on our recently developed model for the equivalent phenomenon of suppressing inhibition (DSI). Furthermore, we derive a simplified formulation of the calcium-mediated endocannabinoid synthesis that underlies short-term modulation of neurotransmission in hippocampus. The simplified model describes cannabinoid-mediated short-term modulation of both hippocampal inhibition and excitation and is ideally suited for large network studies. Moreover, the implementation of the simplified DSI/DSE model provides predictions on how both phenomena are modulated by the magnitude of the pre-synaptic cell's activity. In addition we demonstrate the role of DSE in shaping the post-synaptic cell's firing behaviour qualitatively and quantitatively in dependence on eCB availability and the pre-synaptic cell's activity. Finally, we explore under which conditions the combination of DSI and DSE can temporarily shift the fine balance between excitation and inhibition. This highlights a mechanism by which eCBs might act in a neuro-protective manner during high neural activity.

Journal Article Type Article
Publication Date Aug 16, 2014
Journal Journal of Computational Neuroscience
Print ISSN 0929-5313
Electronic ISSN 1573-6873
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 37
Issue 3
APA6 Citation Zachariou, M., & Thul, R. (2014). Cannabinoid-mediated short-term plasticity in hippocampus. Journal of Computational Neuroscience, 37(3),
Keywords Calcium, DSI, DSE, Endocannabinoids, Hippocampus, Short-term Plasticity
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Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
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Copyright Statement
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