Skip to main content

Research Repository

Advanced Search

Cannabinoid-mediated short-term plasticity in hippocampus

Zachariou, Margarita; Thul, Ruediger

Cannabinoid-mediated short-term plasticity in hippocampus Thumbnail


Margarita Zachariou


Endocannabinoids modulate both excitatory and inhibitory neurotransmission in hippocampus via activation of pre-synaptic cannabinoid receptors. Here, we present a model for cannabinoid mediated short-term depression of excitation (DSE) based on our recently developed model for the equivalent phenomenon of suppressing inhibition (DSI). Furthermore, we derive a simplified formulation of the calcium-mediated endocannabinoid synthesis that underlies short-term modulation of neurotransmission in hippocampus. The simplified model describes cannabinoid-mediated short-term modulation of both hippocampal inhibition and excitation and is ideally suited for large network studies. Moreover, the implementation of the simplified DSI/DSE model provides predictions on how both phenomena are modulated by the magnitude of the pre-synaptic cell's activity. In addition we demonstrate the role of DSE in shaping the post-synaptic cell's firing behaviour qualitatively and quantitatively in dependence on eCB availability and the pre-synaptic cell's activity. Finally, we explore under which conditions the combination of DSI and DSE can temporarily shift the fine balance between excitation and inhibition. This highlights a mechanism by which eCBs might act in a neuro-protective manner during high neural activity.


Zachariou, M., & Thul, R. (2014). Cannabinoid-mediated short-term plasticity in hippocampus. Journal of Computational Neuroscience, 37(3),

Journal Article Type Article
Acceptance Date Jul 21, 2014
Publication Date Aug 16, 2014
Deposit Date Nov 17, 2017
Publicly Available Date Nov 17, 2017
Journal Journal of Computational Neuroscience
Print ISSN 0929-5313
Electronic ISSN 1573-6873
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 37
Issue 3
Keywords Calcium, DSI, DSE, Endocannabinoids, Hippocampus, Short-term Plasticity
Public URL
Publisher URL
Additional Information The final publication is available at via


You might also like

Downloadable Citations